Trial reportJournal of diabetes and its complications
Diabetes, peripheral neuropathy, and lower-extremity function.
Trial report in Journal of diabetes and its complications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Postural Control and Gait Performance in the Diabetic Peripheral Neuropathy: A Systematic Review.BioMed research international · 2016Pooled it
- Sensorimotor and gait training improves proprioception, nerve function, and muscular activation in patients with diabetic peripheral neuropathy: a randomized control trial.Journal of musculoskeletal & neuronal interactions · 2020Trial
- The Antidiabetic Activity of Wild-Growing and Cultivated Medicinal Plants Used in Romania for Diabetes Mellitus Management: A Phytochemical and Pharmacological Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Muscle synergies are largely unaffected in individuals with diabetes who do not have diabetic neuropathy.Clinical biomechanics (Bristol, Avon) · 2025Article
- The Regulate your Sitting Time (RESIT) intervention for reducing sitting time in individuals with type 2 diabetes: findings from a randomised-controlled feasibility trial.Diabetology & metabolic syndrome · 2024Article
- An exploratory study of dynamic foot shape measurements with 4D scanning system.Scientific reports · 2023Article
- Analysis of Diabetic Foot Deformation and Plantar Pressure Distribution of Women at Different Walking Speeds.International journal of environmental research and public health · 2023Article
- Vestibular function for children with insulin dependent diabetes using cervical vestibular evoked myogenic potentials testing.World journal of clinical pediatrics · 2022Article
- Foot deformation analysis with different load-bearing conditions to enhance diabetic footwear designs.PloS one · 2022Article
- Associations of the Glycaemic Control of Diabetes with Dementia and Physical Function in Rural-Dwelling Older Chinese Adults: A Population-Based Study.Clinical interventions in aging · 2021Article
- Improvement of Gait after 4 Weeks of Wearable Focal Muscle Vibration Therapy for Individuals with Diabetic Peripheral Neuropathy.Journal of clinical medicine · 2020Article
- Altered accelerator pedal control in a driving simulator in people with diabetic peripheral neuropathy.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
- The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls.BMC geriatrics · 2018Article
- Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study.Acta diabetologica · 2018Article
- Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus.Scientific reports · 2018Article
- Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study.BMJ (Clinical research ed.) · 2018Article
- Postural sway in individuals with type 2 diabetes and concurrent benign paroxysmal positional vertigo.The International journal of neuroscience · 2017Article
- Long-term Metformin Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans.Journal of the American Geriatrics Society · 2017Article
- Comparison of Gait Speed and Peripheral Nerve Function Between Chronic Kidney Disease Patients With and Without Diabetes.Annals of rehabilitation medicine · 2017Article
- Entrapment neuropathies in diabetes mellitus.World journal of diabetes · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveDiabetes among older adults causes many complications, including decreased lower-extremity function and physical disability. Diabetes can cause peripheral nerve dysfunction, which might be one pathway through which diabetes leads to decreased physical function. The study aims were to determine the following: (1) whether diabetes and impaired fasting glucose are associated with objective measures of physical function in older adults, (2) which peripheral nerve function (PNF) tests are associated with diabetes, and (3) whether PNF mediates the diabetes-physical function relationship. RESEARCH DESIGN AND
methodsThis study included 983 participants, age 65 years and older from the InCHIANTI study. Diabetes was diagnosed by clinical guidelines. Physical performance was assessed using the Short Physical Performance Battery (SPPB), scored from 0 to 12 (higher values, better physical function) and usual walking speed (m/s). PNF was assessed via standard surface electroneurographic study of right peroneal nerve conduction velocity, vibration and touch sensitivity. Clinical cutpoints of PNF tests were used to create a neuropathy score from 0 to 5 (higher values, greater neuropathy). Multiple linear regression models were used to test associations. RESULTS AND
conclusionOne hundred twenty-six (12.8%) participants had diabetes. Adjusting for age, sex, education, and other confounders, diabetic participants had decreased SPPB (β=-0.99; p<0.01), decreased walking speed (β=-0.1m/s; p<0.01), decreased nerve conduction velocity (β=-1.7m/s; p<0.01), and increased neuropathy (β=0.25; p<0.01) compared to non-diabetic participants. Adjusting for nerve conduction velocity and neuropathy score decreased the effect of diabetes on SPPB by 20%, suggesting partial mediation through decreased PNF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.