Evidence map›Paper›PMID 24120132›Full record

ArticleCell2013

Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.

Yehuda Salzberg, Carlos A Díaz-Balzac, Nelson J Ramirez-Suarez, Matthew Attreed, Eillen Tecle, Muriel Desbois, Zaven Kaprielian, Hannes E Bülow

Open access · bronzeAbstract read
In one paragraph

Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 170 citations in OpenAlex.

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  8. The PVD neuron has male-specific structure and mating function inProceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024
    Review
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  18. The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis inFrontiers in cell and developmental biology · 2024
    Article
  19. Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yehuda SalzbergDepartment of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.
Carlos A Díaz-Balzac
Nelson J Ramirez-Suarez
Matthew Attreed
Eillen Tecle
Muriel Desbois
Zaven Kaprielian
Hannes E Bülow
Albert Einstein College of Medicine · USYeshiva University · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Support for the Rose F. Kennedy IDDRCU54HD090260 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MOLHOLM, SOPHIE, WALKLEY, STEVEN UPSHAW · 2016 to 2020
$6.0M
Translational Neuroimaging CoreP30HD071593 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WALKLEY, STEVEN UPSHAW · 2011 to 2015
$5.6M
Genetic Analysis of Kallmann Syndrome in C. elegansR01HD055380 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BUELOW, HANNES ERICH · 2008 to 2012
$1.9M
Establishing the Role of a Novel Conserved Gene in Dendrite MorphogenesisR21NS081505 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BUELOW, HANNES ERICH · 2013 to 2014
$457k
Identification of Novel Loci Interacting with the Kallmann Syndrome Gene Kal-1F31HD066967 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DIAZ-BALZAC, CARLOS ANTONIO · 2010 to 2013
$168k
In vivo analysis of the HS codeF31NS076243 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ATTREED, MATTHEW · 2012 to 2013
$71k
NCI NIH HHS P30 CA013330NCI NIH HHS P30CA013330NICHD NIH HHS 5R01HD055380NICHD NIH HHS F31 HD066967NICHD NIH HHS F31HD066967NICHD NIH HHS P30 HD071593NICHD NIH HHS P30HD071593NICHD NIH HHS R01 HD055380NICHD NIH HHS U54 HD090260NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32GM007288NIGMS NIH HHS T32 GM007491NIGMS NIH HHS T32GM007491NIGMS NIH HHS T32GM07491NINDS NIH HHS F31 NS076243NINDS NIH HHS R21 NS081505NINDS NIH HHS R21NS081505
6 · The paper itself

Abstract

Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"-like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.

Indexed as

Amino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCloning, MolecularDendritesGene Knockdown TechniquesMembrane ProteinsMolecular Sequence DataNeuronsSequence AlignmentCaenorhabditis elegans ProteinsMembrane ProteinsMNR-1 protein, C elegans

Identifiers

PMID24120132
PMCPMC3881433
OpenAlexW2064861953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.