ArticleCell2013
An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 182 citations in OpenAlex.
- Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors.Nature neuroscience · 2026Article
- An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons.Science advances · 2026Article
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- A dendritic guidance receptor functions in both ligand dependent and independent modes.PLoS genetics · 2025Article
- The Upregulation of L1CAM by SVHRSP Mitigates Neuron Damage, Spontaneous Seizures, and Cognitive Dysfunction in a Kainic Acid-Induced Rat Model of Epilepsy.Biomolecules · 2025Article
- SLC-25A46 regulates mitochondrial fusion through the mitofusin protein FZO-1 and is essential for maintaining neuronal morphology.Journal of cell science · 2025Article
- The PVD neuron has male-specific structure and mating function inProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- A dendritic guidance receptor functions in both ligand dependent and independent modes.bioRxiv : the preprint server for biology · 2025Article
- Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia.CNS neuroscience & therapeutics · 2025Review
- Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.eLife · 2025Article
- A method for quantifying parallel growth between neuronal dendritic branches in vitro.PloS one · 2025Article
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Nature communications · 2024Article
- RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching.Genetics · 2024Article
- The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLoS genetics · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in theMolecular biology of the cell · 2024Article
- Proteomic Identification and Label-Free Quantification of Proteins Implicated in Neurite and Spine Formation.Methods in molecular biology (Clifton, N.J.) · 2024Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Robust dendrite morphogenesis is a critical step in the development of reproducible neural circuits. However, little is known about the extracellular cues that pattern complex dendrite morphologies. In the model nematode Caenorhabditis elegans, the sensory neuron PVD establishes stereotypical, highly branched dendrite morphology. Here, we report the identification of a tripartite ligand-receptor complex of membrane adhesion molecules that is both necessary and sufficient to instruct spatially restricted growth and branching of PVD dendrites. The ligand complex SAX-7/L1CAM and MNR-1 function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor. Ectopic expression of SAX-7 and MNR-1 generates a predictable, unnaturally patterned dendritic tree in a DMA-1-dependent manner. Both in vivo and in vitro experiments indicate that all three molecules are needed for interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.