ArticleBiological psychiatry2014
Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analysis of molecular imaging of serotonin transporters in major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Pooled it
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies.Frontiers in computational neuroscience · 2026Review
- More and Less Fear in Serotonin Transporter Knockout Mice.Genes, brain, and behavior · 2025Article
- Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors.Translational psychiatry · 2024Article
- Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety.Nature neuroscience · 2022Article
- Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice.Journal of psychopharmacology (Oxford, England) · 2022Article
- Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective.Brain sciences · 2019Review
- Article
- Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice.Translational psychiatry · 2019Article
- Neural Oscillatory Correlates for Conditioning and Extinction of Fear.Biomedicines · 2018Review
- Inhibition in the amygdala anxiety circuitry.Experimental & molecular medicine · 2018Review
- Modulation of Fear and Arousal Behavior by Serotonin Transporter (5-HTT) Genotypes in Newly Hatched Chickens.Frontiers in behavioral neuroscience · 2018Article
- Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.Biological psychiatry · 2017Review
- Serotonin, Amygdala and Fear: Assembling the Puzzle.Frontiers in neural circuits · 2016Review
- Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Structural bases for neurophysiological investigations of amygdaloid complex of the brain.Scientific reports · 2015Article
- SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice.Genes, brain, and behavior · 2015Article
- Reduced sensitivity to both positive and negative reinforcement in mice over-expressing the 5-hydroxytryptamine transporter.The European journal of neuroscience · 2014Article
- Aversive prediction error signals in the amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGene association studies detect an influence of natural variation in the 5-hydroxytryptamine transporter (5-HTT) gene on multiple aspects of individuality in brain function, ranging from personality traits through to susceptibility to psychiatric disorders such as anxiety and depression. The neural substrates of these associations are unknown. Human neuroimaging studies suggest modulation of the amygdala by 5-HTT variation, but this hypothesis is controversial and unresolved, and difficult to investigate further in humans.
methodsWe used a mouse model in which the 5-HTT is overexpressed throughout the brain and recorded hemodynamic responses (using a novel in vivo voltammetric monitoring method, analogous to blood oxygen level-dependent functional magnetic resonance imaging) and local field potentials during Pavlovian fear conditioning.
resultsIncreased 5-HTT expression impaired, but did not prevent, fear learning and significantly reduced amygdala hemodynamic responses to aversive cues. Increased 5-HTT expression was also associated with reduced theta oscillations, which were a feature of aversive cue presentation in controls. Moreover, in control mice, but not those with high 5-HTT expression, there was a strong correlation between theta power and the amplitude of the hemodynamic response.
conclusionsDirect experimental manipulation of 5-HTT expression levels throughout the brain markedly altered fear learning, amygdala hemodynamic responses, and neuronal oscillations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.