ArticleAcademic radiology2013
Scatter correction associated with dedicated dual-source CT hardware improves accuracy of lung air measures.
Article in Academic radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 17 citations in OpenAlex.
- A modified method of lung tissue volume measurement using computed tomography numbers.Japanese journal of radiology · 2026Article
- Article
- Single-material beam hardening correction via an analytical energy response model for diagnostic CT.Medical physics · 2022Article
- Feasibility of multi-contrast imaging on dual-source photon counting detector (PCD) CT: An initial phantom study.Medical physics · 2019Article
- Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population.International journal of chronic obstructive pulmonary disease · 2019Article
- Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.Chest · 2018Article
- SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.American journal of respiratory and critical care medicine · 2016Article
- Lung Tissue Volume is Elevated in Obesity and Reduced by Bariatric Surgery.Obesity surgery · 2016Article
- Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model.Toxicologic pathology · 2016Article
- Improved CT-based estimate of pulmonary gas trapping accounting for scanner and lung-volume variations in a multicenter asthmatic study.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study.Annals of the American Thoracic Society · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
RATIONALE AND
objectivesAccurate assessment of air density used to quantitatively characterize amount and distribution of emphysema in chronic obstructive pulmonary disease (COPD) subjects has remained challenging. Hounsfield units (HU) within tracheal air can be considerably less negative than -1000 HU. This study has sought to characterize the effects of improved scatter correction used in dual-source pulmonary computed tomography (CT). MATERIALS AND
methodsDual-source dual-energy (DSDE) and single-source (SS) scans taken at multiple energy levels and scan settings were acquired for quantitative comparison using anesthetized ovine (n = 6), swine (n = 13), and a lung phantom. Data were evaluated for the lung, inferior vena cava, and tracheal segments. To minimize the effect of cross-scatter, the phantom scans in the DSDE mode were obtained by reducing the current of one of the tubes to near zero.
resultsA significant shift in mean HU values in the tracheal regions of animals and the phantom is observed, with values consistently closer to -1000 HU in DSDE mode. HU values associated with SS mode demonstrated a positive shift of up to 32 HU. In vivo tracheal air measurements demonstrated considerable variability with SS scanning, whereas these values were more consistent with DSDE imaging. Scatter effects in the lung parenchyma differed from adjacent tracheal measures.
conclusionData suggest that the scatter correction introduced into the dual-energy mode of imaging has served to provide more accurate CT lung density measures sought to quantitatively assess the presence and distribution of emphysema in COPD subjects. Data further suggest that CT images, acquired without adequate scatter correction, cannot be corrected by linear algorithms given the variability in tracheal air HU values and the independent scatter effects on lung parenchyma.
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