ArticleJournal of physiological anthropology2013
Association between melanopsin gene polymorphism (I394T) and pupillary light reflex is dependent on light wavelength.
Article in Journal of physiological anthropology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Human melanopsin (OPN4) gene polymorphisms: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Melanopsin gene polymorphism and volumetric change in the left hippocampal dentate gyrus following light therapy in mood disorders: An exploratory study.Frontiers in psychiatry · 2026Article
- Daylights with high melanopsin stimulation appear reddish in fovea and greenish in periphery.PloS one · 2023Article
- Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans.International journal of environmental research and public health · 2021Article
- The Role of Daylight for Humans: Gaps in Current Knowledge.Clocks & sleep · 2020Article
- A review of the studies on nonvisual lighting effects in the field of physiological anthropology.Journal of physiological anthropology · 2019Review
- Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases.Frontiers in neurology · 2019Review
- Functional characterisation of naturally occurring mutations in human melanopsin.Cellular and molecular life sciences : CMLS · 2018Article
- Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue.Human molecular genetics · 2018Article
- Subadditive responses to extremely short blue and green pulsed light on visual evoked potentials, pupillary constriction and electroretinograms.Journal of physiological anthropology · 2017Article
- Quadrant Field Pupillometry Detects Melanopsin Dysfunction in Glaucoma Suspects and Early Glaucoma.Scientific reports · 2016Article
- Effect of simultaneous exposure to extremely short pulses of blue and green light on human pupillary constriction.Journal of physiological anthropology · 2016Article
- Article
- Light-sensitive brain pathways and aging.Journal of physiological anthropology · 2016Review
- Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students.Journal of physiological anthropology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur aim was to determine the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.
methodsA total of 195 visually corrected subjects volunteered for investigation of the melanopsin gene of single nucleotide polymorphism (SNP) of rs1079610 (I394T). The genotype groups were TT (n = 126), TC (n = 55), and CC (n = 8), and 75 of the subjects, including subjects with TT (n = 34), TC (n = 33), and CC (n = 8) participated in our experiment. Three monochromatic lights with peak wavelengths of 465 nm (blue), 536 nm (green), and 632 nm (red) were prepared, and each light was projected to the subjects with five intensities, 12, 13, 14, 14.5 and 15 log photons/(cm2 s), for one minute. The pupil size of the left eye was measured under each light condition after a 1-minute adaptation.
resultsThe pupils of the TC + CC genotypes (n = 38) were significantly smaller than those of the TT genotype (n = 31) under a blue (463 nm) light condition with 15 log photons/(cm2 s) (P < 0.05). In contrast, there were no significant differences under green (536 nm) and red (632 nm) light conditions. Conversely, relative pupil constrictions of the TC + CC genotypes were greater than those of the TT genotype under both blue and green conditions with high intensities (14.5 and 15 log photons/(cm2 s)). In contrast, there were no significant differences between genotype groups in pupil size and relative pupilloconstriction under the red light conditions.
conclusionsOur findings suggest that the melanopsin gene polymorphism (I394T) functionally interacts with pupillary light reflex, depending on light intensity and, particularly, wavelength, and that under a light condition fulfilling both high intensity and short wavelength, the pupillary light response of subjects with the C allele (TC + CC) is more sensitive to light than that of subjects with the TT genotype.
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