ArticleMolecular ecology resources2014
A new multiplex SNP genotyping assay for detecting hybridization and introgression between the M and S molecular forms of Anopheles gambiae.
Article in Molecular ecology resources, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 31 citations in OpenAlex.
- Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds.BMC genomics · 2024Article
- Patterns of Gene Flow inEvolutionary applications · 2024Article
- Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B.Parasites & vectors · 2022Article
- Perfect association between spatial swarm segregation and the X-chromosome speciation island in hybridizing Anopheles coluzzii and Anopheles gambiae populations.Scientific reports · 2022Article
- Advances and opportunities in malaria population genomics.Nature reviews. Genetics · 2021Review
- Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae.Molecular ecology resources · 2021Article
- Unravelling population structure heterogeneity within the genome of the malaria vector Anopheles gambiae.BMC genomics · 2021Article
- Unveiling mosquito cryptic species and their reproductive isolation.Insect molecular biology · 2020Review
- The influence of anthropogenic habitat fragmentation on the genetic structure and diversity of the malaria vector Anopheles cruzii (Diptera: Culicidae).Scientific reports · 2020Article
- Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection.Malaria journal · 2019Article
- Mitochondrial genomes ofF1000Research · 2018Article
- The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal.Malaria journal · 2017Article
- Comparing efficacy of a sweep net and a dip method for collection of mosquito larvae in large bodies of water in South Africa.F1000Research · 2016Article
- Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.PLoS pathogens · 2015Review
- A multi-detection assay for malaria transmitting mosquitoes.Journal of visualized experiments : JoVE · 2015Article
- Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Absence of kdr resistance alleles in the Union of the Comoros, East Africa.F1000Research · 2015Article
- Article
- Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa.F1000Research · 2014Article
- Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The M and S forms of Anopheles gambiae have been the subject of intense study, but are morphologically indistinguishable and can only be identified using molecular techniques. PCR-based assays to distinguish the two forms have been designed and applied widely. However, the application of these assays towards identifying hybrids between the two forms, and backcrossed hybrids in particular, has been problematic as the currently available diagnostic assays are based on single locus and/or are located within a multicopy gene. Here, we present an alternative genotyping method for detecting hybridization and introgression between M and S molecular forms based on a multilocus panel of single-nucleotide polymorphisms (SNPs) fixed between the M and S forms. The panel of SNPs employed is located in so-called islands of divergence leading us to describe this method as the 'Divergence Island SNP' (DIS) assay. We show this multilocus SNP genotyping approach can robustly and accurately detect F1 hybrids as well as backcrossed individuals.
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