Evidence map›Paper›PMID 24119078›Full record

ReviewMicrobial biotechnology2013

Recombinant DNA production of spider silk proteins.

Olena Tokareva, Valquíria A Michalczechen-Lacerda, Elíbio L Rech, David L Kaplan

Open access · goldAbstract readReview
In one paragraph

Review in Microbial biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Design and Heterologous Production of Bagworm Silk-Inspired Proteins inComputational and structural biotechnology journal · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Multicomponent nature underlies the extraordinary mechanical properties of spider dragline silk.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Molecular Dynamics of Synthetic Flagelliform Silk Fiber Assembly.Macromolecular materials and engineering · 2021
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Olena TokarevaDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Valquíria A Michalczechen-Lacerda
Elíbio L Rech
David L Kaplan
Tufts University · USBrazilian Agricultural Research Corporation · BRUniversidade de Brasília · BR

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Models to Predict Protein Biomaterial PerformanceU01EB014976 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI BUEHLER, MARKUS J., KAPLAN, DAVID L. · 2012 to 2020
$5.2M
Silica-protein Nanocomposites for Dental RepairR01DE017207 · NIDCR · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2007 to 2016
$3.0M
Tissue Engineering Cornea ReplacementsR01EY020856 · NEI · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2010 to 2016
$2.7M
Multifunctional Tropoelastin-Silk Biomaterial SystemsR01EB014283 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2012 to 2015
$1.2M
NEI NIH HHS EY020856NEI NIH HHS R01 EY020856NIBIB NIH HHS EB002520NIBIB NIH HHS EB014283NIBIB NIH HHS EB014976NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R01 EB014283NIBIB NIH HHS U01 EB014976NIDCR NIH HHS DE017207NIDCR NIH HHS R01 DE017207
6 · The paper itself

Abstract

Spider dragline silk is considered to be the toughest biopolymer on Earth due to an extraordinary combination of strength and elasticity. Moreover, silks are biocompatible and biodegradable protein-based materials. Recent advances in genetic engineering make it possible to produce recombinant silks in heterologous hosts, opening up opportunities for large-scale production of recombinant silks for various biomedical and material science applications. We review the current strategies to produce recombinant spider silks.

Indexed as

AnimalsArthropod ProteinsBiopolymersBiotechnologyDNA, RecombinantRecombinant ProteinsSilkArthropod ProteinsBiopolymersDNA, RecombinantRecombinant ProteinsSilk

Identifiers

PMID24119078
PMCPMC3815454
OpenAlexW2107631853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.