ArticleThe European journal of neuroscience2013
Avoidance-based human Pavlovian-to-instrumental transfer.
Article in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms.Psychopharmacology · 2019Trial
- Dopamine D2/3- and μ-opioid receptor antagonists reduce cue-induced responding and reward impulsivity in humans.Translational psychiatry · 2016Trial
- Serotonin and dopamine differentially affect appetitive and aversive general Pavlovian-to-instrumental transfer.Psychopharmacology · 2015Trial
- Online and in-person stress induction in a quasi-avoidance-based Pavlovian-to-instrumental transfer task.Learning & behavior · 2026Article
- Pavlovian to instrumental transfer of control over fight or flight decisions.NPJ science of learning · 2025Article
- Cortical Beta Power Reflects the Influence of Pavlovian Cues on Human Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motivational control of habits: A preregistered fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex differences in motivational biases over instrumental actions.NPJ science of learning · 2024Article
- Alcohol Approach Bias Is Associated With Both Behavioral and Neural Pavlovian-to-Instrumental Transfer Effects in Alcohol-Dependent Patients.Biological psychiatry global open science · 2023Article
- Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study.Scientific reports · 2023Article
- The value of an action: Impact of motor behaviour on outcome processing and stimulus preference.The European journal of neuroscience · 2022Article
- Review
- Measuring maladaptive avoidance: from animal models to clinical anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- General Pavlovian-to-instrumental transfer in humans: Evidence from Bayesian inference.Frontiers in behavioral neuroscience · 2022Article
- Effective Connectivity during an Avoidance-Based Pavlovian-to-Instrumental Transfer Task.Brain sciences · 2021Article
- Human appetitive Pavlovian-to-instrumental transfer: a goal-directed account.Psychological research · 2021Review
- The Protective Effects of Perceived Control During Repeated Exposure to Aversive Stimuli.Frontiers in neuroscience · 2021Article
- Article
- Motivational factors underlying aversive Pavlovian-instrumental transfer.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
Corrections and comments
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4 authors.
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Abstract
The Pavlovian-to-instrumental transfer (PIT) paradigm probes the influence of Pavlovian cues over instrumentally learned behavior. The paradigm has been used extensively to probe basic cognitive and motivational processes in studies of animal learning. More recently, PIT and its underlying neural basis have been extended to investigations in humans. These initial neuroimaging studies of PIT have focused on the influence of appetitively conditioned stimuli on instrumental responses maintained by positive reinforcement, and highlight the involvement of the striatum. In the current study, we sought to understand the neural correlates of PIT in an aversive Pavlovian learning situation when instrumental responding was maintained through negative reinforcement. Participants exhibited specific PIT, wherein selective increases in instrumental responding to conditioned stimuli occurred when the stimulus signaled a specific aversive outcome whose omission negatively reinforced the instrumental response. Additionally, a general PIT effect was observed such that when a stimulus was associated with a different aversive outcome than was used to negatively reinforce instrumental behavior, the presence of that stimulus caused a non-selective increase in overall instrumental responding. Both specific and general PIT behavioral effects correlated with increased activation in corticostriatal circuitry, particularly in the striatum, a region involved in cognitive and motivational processes. These results suggest that avoidance-based PIT utilizes a similar neural mechanism to that seen with PIT in an appetitive context, which has implications for understanding mechanisms of drug-seeking behavior during addiction and relapse.
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Registered trials
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