ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2014
Invariant natural killer T cells in children with eosinophilic esophagitis.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Minimally invasive biomarker studies in eosinophilic esophagitis: A systematic review.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Pooled it
- Review
- Potential Aspects of the Use of Cytokines in Atopic Dermatitis.Biomedicines · 2024Review
- Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis.Frontiers in immunology · 2024Article
- Mechanistic Insights into Eosinophilic Esophagitis: Therapies Targeting Pathophysiological Mechanisms.Cells · 2023Review
- Current Practice in Pediatric Cow's Milk Protein Allergy-Immunological Features and Beyond.International journal of molecular sciences · 2023Review
- Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis.Frontiers in immunology · 2023Review
- Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets.Frontiers in physiology · 2021Review
- Review
- Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.International journal of molecular sciences · 2020Review
- Significance of Interleukin (IL)-15 in IgE associated eosinophilic Esophagitis (EoE).International journal of basic and clinical immunology · 2019Article
- Cow's Milk Allergy: Immunomodulation by Dietary Intervention.Nutrients · 2019Review
- Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor.Scientific reports · 2019Article
- Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications.Expert review of clinical immunology · 2019Review
- Pathophysiology of Eosinophilic Esophagitis.Clinical reviews in allergy & immunology · 2018Review
- New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting.The Journal of allergy and clinical immunology · 2018Article
- Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis.Clinical and translational gastroenterology · 2018Article
- Elevated expression of activated TAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Pathophysiology of Eosinophilic Esophagitis.Gastroenterology · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundEosinophilic esophagitis (EoE) is an atopic disease characterized by eosinophilic inflammation in which dietary antigens (in particular, milk) play a major role. EoE is most likely a mixed IgE and non-IgE food-mediated reaction in which overexpression of Th2 cytokines, particularly IL-13, play a major role; however, the cells responsible for IL-13 overexpression remain elusive. Th2-cytokines are secreted following the ligation of invariant natural killer T cell receptors to sphingolipids (SLs). Sphingolipids (SLs) are presented via the CD1d molecule on the INKTs surface. Cow's milk-derived SL has been shown to activate iNKTs from children with IgE-mediated food allergies to milk (FA-MA) to produce Th2 cytokines. The role of iNKTs and milk-SL in EoE pathogenesis is currently unknown.
objectiveThe aim of this study was to investigate the role of iNKTs and milk-SL in EoE.
methodsPeripheral blood mononuclear cells (PBMCs) from 10 children with active EoE (EoE-A), 10 children with controlled EoE (EoE-C) and 16 healthy controls (non-EoE) were measured ex vivo and then incubated with α-galactosylceramide (αGal) and milk-SL. INKTs from peripheral blood (PB) and oesophageal biopsies were studied.
resultsEoE-A children had significantly fewer peripheral blood iNKTs with a greater Th2-response to αGal and milk-SM compared with iNKTs of EoE-C and non-EoE children. Additionally, EoE-A children had increased iNKT levels in oesophageal biopsies compared with EoE-C children.
conclusionMilk-SLs are able to activate peripheral blood iNKTs in EoE-A children to produce Th2 cytokines. Additionally, iNKT levels are higher at the site of active oesophageal eosinophilic inflammation. CLINICAL RELEVANCE: This study suggests that sphingolipids (SLs) contained in milk may drive the development of EoE by promoting an iNKT-cell-mediated Th2-type cytokine response that facilitates eosinophil-mediated allergic inflammation.
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