ArticleThe Plant journal : for cell and molecular biology2013
Increased leaf mesophyll porosity following transient retinoblastoma-related protein silencing is revealed by microcomputed tomography imaging and leads to a system-level physiological response to the altered cell division pattern.
Article in The Plant journal : for cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- High-resolution microCT reveals relationships between stomata and interior leaf anatomy in sorghum.Plant physiology · 2026Article
- Subcellular plant carbohydrate metabolism under elevated temperature.Plant physiology · 2025Article
- CLASP balances two competing cell division plane cues during leaf development.Nature plants · 2022Article
- Ploidy influences wheat mesophyll cell geometry, packing and leaf function.Plant direct · 2021Article
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- In silico study of the role of cell growth factors in photosynthesis using a virtual leaf tissue generator coupled to a microscale photosynthesis gas exchange model.Journal of experimental botany · 2020Article
- Mesophyll porosity is modulated by the presence of functional stomata.Nature communications · 2019Article
- Micron-scale Phenotyping Techniques of Maize Vascular Bundles Based on X-ray Microcomputed Tomography.Journal of visualized experiments : JoVE · 2018Article
- Arabidopsis Leaf Flatness Is Regulated by PPD2 and NINJA through Repression ofPlant physiology · 2018Article
- Investigating the microstructure of plant leaves in 3D with lab-based X-ray computed tomography.Plant methods · 2018Article
- High throughput phenotyping of morpho-anatomical stem properties using X-ray computed tomography in sorghum.Plant methods · 2018Article
- Cell density and airspace patterning in the leaf can be manipulated to increase leaf photosynthetic capacity.The Plant journal : for cell and molecular biology · 2017Article
- Macro optical projection tomography for large scale 3D imaging of plant structures and gene activity.Journal of experimental botany · 2017Article
- Non-destructive, high-content analysis of wheat grain traits using X-ray micro computed tomography.Plant methods · 2017Article
- Non-destructive determination of floral staging in cereals using X-ray micro computed tomography (µCT).Plant methods · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
The causal relationship between cell division and growth in plants is complex. Although altered expression of cell-cycle genes frequently leads to altered organ growth, there are many examples where manipulation of the division machinery leads to a limited outcome at the level of organ form, despite changes in constituent cell size. One possibility, which has been under-explored, is that altered division patterns resulting from manipulation of cell-cycle gene expression alter the physiology of the organ, and that this has an effect on growth. We performed a series of experiments on retinoblastoma-related protein (RBR), a well characterized regulator of the cell cycle, to investigate the outcome of altered cell division on leaf physiology. Our approach involved combination of high-resolution microCT imaging and physiological analysis with a transient gene induction system, providing a powerful approach for the study of developmental physiology. Our investigation identifies a new role for RBR in mesophyll differentiation that affects tissue porosity and the distribution of air space within the leaf. The data demonstrate the importance of RBR in early leaf development and the extent to which physiology adapts to modified cellular architecture resulting from altered cell-cycle gene expression.
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Registered trials
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