ArticleAddiction biology2015
Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.
Article in Addiction biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models.Current topics in behavioral neurosciences · 2025Review
- Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats.Neuroscience and biobehavioral reviews · 2021Review
- Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells.Development (Cambridge, England) · 2021Article
- RNA-Seq Analysis of Genetic and Transcriptome Network Effects of Dual-Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models.Alcoholism, clinical and experimental research · 2020Article
- MurineEMBO molecular medicine · 2019Article
- Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans.Invertebrate neuroscience : IN · 2018Article
- Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal, Consumption, and Conditioned Place Preference.Frontiers in genetics · 2018Article
- Genetic studies of alcohol dependence in the context of the addiction cycle.Neuropharmacology · 2017Review
- The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy.Epilepsy & behavior : E&B · 2017Review
- Differential Expression of Munc13-2 Produces Unique Synaptic Phenotypes in the Basolateral Amygdala of C57BL/6J and DBA/2J Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia.BMC genomics · 2016Article
- Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.Alcoholism, clinical and experimental research · 2014Article
- Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal.Genes, brain, and behavior · 2014Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knockout heterozygote (Mpdz(+/-) ) mice, with increased (2.9-fold) and decreased (53%) target expression, respectively. Both models differ in EW compared with wild-type littermates (P ≤ 0.03), providing compelling evidence for an inverse relationship between Mpdz expression and EW severity. Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.
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Registered trials
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