SynthesisClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2013
Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis.
Synthesis in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 7 syntheses or guidelines pooled it, 268 citations in OpenAlex.
- Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis.Clinical reviews in allergy & immunology · 2024Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis.Allergy · 2022Pooled it
- Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis.The journal of allergy and clinical immunology. In practice · 2022Pooled it
- Improvement in Health-Related Quality of Life in Food-Allergic Patients: A Meta-Analysis.The journal of allergy and clinical immunology. In practice · 2021Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2021Pooled it
- Biomarkers associated with persistence and severity of IgE-mediated food allergies: a systematic review.Jornal de pediatriaPooled it
- Incidence of food allergic reactions among adolescents engaged in food allergy management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025Trial
- Desensitization and remission after peanut sublingual immunotherapy in 1- to 4-year-old peanut-allergic children: A randomized, placebo-controlled trial.The Journal of allergy and clinical immunology · 2024Trial
- Open-label study of the efficacy, safety, and durability of peanut sublingual immunotherapy in peanut-allergic children.The Journal of allergy and clinical immunology · 2023Trial
- Trial
- Safety of live attenuated influenza vaccine in young people with egg allergy: multicentre prospective cohort study.BMJ (Clinical research ed.) · 2015Trial
- An In Silico Omics Investigation of the Lactobacillus Genus Complex for Allergenicity Mitigation.Immunity, inflammation and disease · 2026Article
- You Can't Hold Their Hand the Whole Time: A Qualitative Study of Parents' Experiences of Adolescents With Food Allergy.Journal of advanced nursing · 2026Article
- Identifying and Prioritising BSACI Service Standards for Paediatric Allergy in the United Kingdom.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- A critical case of anaphylaxis triggered by exercise in a pediatric asthma patient.BMC pediatrics · 2025Article
- Walnut Allergy in Children: A Diagnostic Test Accuracy Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry.Allergy · 2025Article
- Emergency Monitoring Following A Diagnosis of Anaphylaxis.Current allergy and asthma reports · 2025Review
- Online food allergy and anaphylaxis education for school personnel is effective and scalable: experience with the allergyaware e-learning portal from 2015 to 2022.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundFood allergy is a common cause of anaphylaxis, but the incidence of fatal food anaphylaxis is not known. The aim of this study was to estimate the incidence of fatal food anaphylaxis for people with food allergy and relate this to other mortality risks in the general population.
methodsWe undertook a systematic review and meta-analysis, using the generic inverse variance method. Two authors selected studies by consensus, independently extracted data and assessed the quality of included studies using the Newcastle-Ottawa assessment scale. We searched Medline, Embase, PsychInfo, CINAHL, Web of Science, LILACS or AMED, between January 1946 and September 2012, and recent conference abstracts. We included registries, databases or cohort studies which described the number of fatal food anaphylaxis cases in a defined population and time period and applied an assumed population prevalence rate of food allergy.
resultsWe included data from 13 studies describing 240 fatal food anaphylaxis episodes over an estimated 165 million food-allergic person-years. Study quality was mixed, and there was high heterogeneity between study results, possibly due to variation in food allergy prevalence and data collection methods. In food-allergic people, fatal food anaphylaxis has an incidence rate of 1.81 per million person-years (95%CI 0.94, 3.45; range 0.63, 6.68). In sensitivity analysis with different estimated food allergy prevalence, the incidence varied from 1.35 to 2.71 per million person-years. At age 0-19, the incidence rate is 3.25 (1.73, 6.10; range 0.94, 15.75; sensitivity analysis 1.18-6.13). The incidence of fatal food anaphylaxis in food-allergic people is lower than accidental death in the general European population.
conclusionFatal food anaphylaxis for a food-allergic person is rarer than accidental death in the general population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.