Trial reportPaediatric and perinatal epidemiology2013
A randomised trial to evaluate the effects of low-dose aspirin in gestation and reproduction: design and baseline characteristics.
Trial report in Paediatric and perinatal epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 97 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Impact of preconception, pregnancy, and postpartum culinary nutrition education interventions: a systematic review.Nutrition reviews · 2021Pooled it
- Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.The Cochrane database of systematic reviews · 2020Pooled it
- Antiplatelet agents for preventing pre-eclampsia and its complications.The Cochrane database of systematic reviews · 2019Pooled it
- Periconception Maternal-Serum Vitamin D, Vaginal Bleeding, and Subchorionic Hemorrhage in Early Pregnancy.Nutrients · 2026Trial
- Influence of Gestational Age Measurement Technique on the Associations Between Maternal Characteristics and Birth Outcomes.Paediatric and perinatal epidemiology · 2026Trial
- Preconception vitamin D status and subsequent risk of preeclampsia: A secondary cohort analysis from the EAGeR trial.Pregnancy hypertension · 2026Trial
- Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss.Human reproduction (Oxford, England) · 2025Trial
- Preconception Chlamydia trachomatis seropositivity and fecundability, live birth, and adverse pregnancy outcomes.Fertility and sterility · 2025Trial
- The Role of Maternal Preconception Adiposity in Human Offspring Sex and Sex Ratio.American journal of epidemiology · 2023Trial
- Preconception caffeine metabolites, caffeinated beverage intake, and fecundability.The American journal of clinical nutrition · 2022Trial
- The Safety of Low-Dose Aspirin on the Mode of Delivery: Secondary Analysis of the Effect of Aspirin in Gestation and Reproduction Randomized Controlled Trial.American journal of perinatology · 2022Trial
- Use of Machine Learning to Estimate the Per-Protocol Effect of Low-Dose Aspirin on Pregnancy Outcomes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles.Human reproduction (Oxford, England) · 2021Trial
- The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin-Detected Pregnancy, Pregnancy Loss, and Live Birth : Per Protocol Analysis of a Randomized Trial.Annals of internal medicine · 2021Trial
- Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study.Paediatric and perinatal epidemiology · 2021Trial
- Low-dose aspirin in reproductive health: effects on menstrual cycle characteristics.Fertility and sterility · 2020Trial
- Preconception Blood Pressure and Its Change Into Early Pregnancy: Early Risk Factors for Preeclampsia and Gestational Hypertension.Hypertension (Dallas, Tex. : 1979) · 2020Trial
- Maternal fatty acid concentrations and newborn DNA methylation.The American journal of clinical nutrition · 2020Trial
- Physical activity and incidence of subclinical and clinical pregnancy loss: a secondary analysis in the effects of aspirin in gestation and reproduction randomized trial.Fertility and sterility · 2020Trial
- Maternal preconception lipid profile and gestational lipid changes in relation to birthweight outcomes.Scientific reports · 2020Trial
37 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundLow-dose aspirin (LDA) has been proposed to improve pregnancy outcomes in couples experiencing recurrent pregnancy loss. However, results from studies of LDA on pregnancy outcomes have been inconsistent, perhaps because most studies evaluated LDA-initiated post-conception. The purpose of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was to determine whether preconception-initiated LDA improves livebirth rates in women with one to two prior losses.
methodsWe performed a multicentre, block randomised, double-blind, placebo-controlled trial. Study participants were recruited using community-based advertisements and physician referral to four university medical centres in the US (2006-12). Eligible women were aged 18-40 years actively trying to conceive, with one to two prior losses. Participants were randomised to receive daily LDA (81 mg/day) or a matching placebo, and all were provided with daily 400-mcg folic acid. Follow-up continued for ≤6 menstrual cycles while attempting to conceive. For those who conceived, treatment was continued until 36 weeks gestation. The primary outcome was the cumulative livebirth rate over the trial period.
resultsThere were 1228 women randomised (615 LDA, 613 placebo). Participants had a mean age of 28.7, were mostly white (95%), well educated (86% more than high school education), and employed (75%) with a household income >$100 000 annually (40%). The characteristics of those in the treatment and placebo arms were well balanced.
conclusionsWe describe the study design, recruitment, data collection, and baseline characteristics of participants enrolled in EAGeR, which aimed to determine the effect of LDA on livebirth and other pregnancy outcomes in these women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.