ReviewBritish journal of clinical pharmacology2014
Pharmacological strategies for detoxification.
Review in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Barriers and facilitators to detoxification from opioid substitution treatment: A mixed-methods systematic review.Addiction (Abingdon, England) · 2026Pooled it
- Evidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology.Journal of psychopharmacology (Oxford, England) · 2026Guideline
- Home-based detoxification for individuals with alcohol or drug dependence: A systematic review of the recent literature.Drug and alcohol review · 2025Pooled it
- Effectiveness of non-opioid interventions to reduce opioid withdrawal symptoms in patients with chronic pain: a systematic review.Family practice · 2022Pooled it
- Efficacy and Safety of Fentanyl in Combination with Midazolam in Children on Mechanical Ventilation.Journal of Korean medical science · 2019Trial
- Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial.Journal of addiction medicineTrial
- Does Genetic Variation in Detoxification Capacity Influence Hepatic Biomarker Responses to a Liver Support Supplementation Regimen?International journal of molecular sciences · 2025Article
- Expecting medication misuse: a proactive approach to drug discovery to prevent fatal overdose.Future medicinal chemistry · 2025Review
- Identification of Benzodiazepine Use Based on Dried Blood Stains Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Abdominal Pain in Inflammatory Bowel Disease: An Evidence-Based, Multidisciplinary Review.Crohn's & colitis 360 · 2023Article
- The traps of adaptation: Addiction as maladaptive referent-dependent evaluation.Cognitive, affective & behavioral neuroscience · 2023Review
- The Impact of Qigong and Tai Chi Exercise on Drug Addiction: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Article
- Drug deprescription-withdrawal risk, prevention, and treatment.Proceedings (Baylor University. Medical Center) · 2020Review
- Auricular neural stimulation as a new non-invasive treatment for opioid detoxification.Bioelectronic medicine · 2020Review
- The past, present and future of opioid withdrawal assessment: a scoping review of scales and technologies.BMC medical informatics and decision making · 2019Article
- Mini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry.Current drug research reviews · 2019Review
- Challenges of the pharmacological management of benzodiazepine withdrawal, dependence, and discontinuation.Therapeutic advances in psychopharmacology · 2018Review
- Treatment Strategies for the Opioid-Dependent Patient.Current pain and headache reports · 2017Review
- Article
- Use of pharmacotherapies in the treatment of alcohol use disorders and opioid dependence in primary care.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detoxification refers to the safe discontinuation from a substance of dependence and is distinct from relapse prevention. Detoxification usually takes between a few days and a few weeks to complete, depending on the substance being misused, the severity of dependence and the support available to the user. Psychosocial therapies alongside pharmacological treatments are essential to improve outcome. The dependencies considered in this overview are detoxification from opioids (with methadone, buprenorphine, α2-adrenoceptor agonists and adjunct medications), alcohol (with benzodiazepines, anti-glutamatergics and γ-aminobutyric acid (GABA)-ergic drugs), stimulants and cannabis (with no clear recommended pharmacological treatments), benzodiazepines (with dose tapering) and nicotine (with nicotine replacement therapy, antidepressants and partial agonists). Evidence is limited by a lack of controlled trials robust enough for review bodies, and more research is required into optimal treatment doses and regimes, alone and in combination.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.