ReviewImmunological reviews2013
From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells.
Review in Immunological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Dynamic Metabolic Profiling and Diagnostic Biomarkers of Acute Graft-Versus-Host Disease Based on Metabolomics.Biomedical chromatography : BMC · 2026Article
- The application and prospect of granzyme B-targeted PET imaging in cancer immunotherapy.Journal of translational medicine · 2025Review
- Mechanoregulation of lymphocyte cytotoxicity.Nature reviews. Immunology · 2025Review
- Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport.Leukemia · 2025Review
- Multi-omics Analysis Reveals Key Gut Microbiota and Metabolites Closely Associated with Huntington's Disease.Molecular neurobiology · 2025Article
- Comparative Lipidomics Analysis Provides New Insights into the Metabolic Basis of Color Formation in Green Cotton Fiber.Plants (Basel, Switzerland) · 2024Article
- Untargeted Plasma Lipidomics Reveal Perturbed Metabolites of Glycerophospholipids, and Sphingolipids in Moderate-to-Severe Acne.Clinical, cosmetic and investigational dermatology · 2023Article
- Metabolomics Reveals Molecular Signatures for Psoriasis Biomarkers and Drug Targets Discovery.Clinical, cosmetic and investigational dermatology · 2023Article
- Nanotopography modulates cytoskeletal organization and dynamics during T cell activation.Molecular biology of the cell · 2022Article
- Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity.Nature communications · 2022Article
- Lymphocyte Polarization During Immune Synapse Assembly: Centrosomal Actin Joins the Game.Frontiers in immunology · 2022Review
- Actomyosin dynamics modulate microtubule deformation and growth during T-cell activation.Molecular biology of the cell · 2021Article
- UPLC-MS/MS-Based Rat Serum Metabolomics Reveals the Detoxification Mechanism of Psoraleae Fructus during Salt Processing.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.Science (New York, N.Y.) · 2020Article
- Differential Metabolic Alterations and Biomarkers Between Gastric Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis.OncoTargets and therapy · 2020Article
- A distinct glycerophospholipid metabolism signature of acute graft versus host disease with predictive value.JCI insight · 2019Article
- Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis.GigaScience · 2017Article
- Centrosome positioning in non-dividing cells.Protoplasma · 2016Review
- Orchestrating Lymphocyte Polarity in Cognate Immune Cell-Cell Interactions.International review of cell and molecular biology · 2016Review
- Actin depletion initiates events leading to granule secretion at the immunological synapse.Immunity · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In T lymphocytes, polarization of the microtubule-organizing center (MTOC) to the immunological synapse enables the directional secretion of cytokines, cytolytic factors, and other soluble molecules toward the antigen-presenting cell. This is likely to be crucial for maintaining the specificity of T-cell effector responses. Here, we review recent advances in our understanding of MTOC reorientation in T cells, focusing first on the importance of diacylglycerol and protein kinase C isozymes and then on the molecular motor proteins that function downstream to drive MTOC movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.