ArticleAlimentary pharmacology & therapeutics2013
Significantly higher frequency of Helicobacter suis in patients with idiopathic parkinsonism than in control patients.
Article in Alimentary pharmacology & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association ofFrontiers in medicine · 2025Pooled it
- Non-International journal of molecular sciences · 2024Pooled it
- Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies.Brain and behavior · 2020Pooled it
- Article
- Therapies for Parkinson's disease and the gut microbiome: evidence for bidirectional connection.Frontiers in aging neuroscience · 2023Review
- Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health.Veterinary research · 2022Review
- Presence ofJournal of personalized medicine · 2022Article
- Insights into the roles of bacterial infection and antibiotics in Parkinson's disease.Frontiers in cellular and infection microbiology · 2022Review
- Evaluation of Inflammatory Cytokine and AntiMiddle East journal of digestive diseases · 2022Article
- Update to the Treatment of Parkinson's Disease Based on the Gut-Brain Axis Mechanism.Frontiers in neuroscience · 2022Review
- Parkinson's Disease and the Metal-Microbiome-Gut-Brain Axis: A Systems Toxicology Approach.Antioxidants (Basel, Switzerland) · 2021Review
- GastricInternational journal of molecular sciences · 2021Article
- Isolation and characterization ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Adhesion ofFrontiers in molecular biosciences · 2021Review
- Effects of Helicobacter pylori on Levodopa Pharmacokinetics.Journal of Parkinson's disease · 2021Review
- Parkinson's disease: Are gut microbes involved?American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Role ofJournal of clinical medicine · 2020Review
- Review
- Altered Gut Microbiome and Intestinal Pathology in Parkinson's Disease.Journal of movement disorders · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increased proportional mortality from Parkinson's disease amongst livestock farmers. The hypokinesia of Parkinson's disease has been linked to Helicobacter pylori. H. suis is the most common zoonotic helicobacter in man.
aimTo compare the frequency of H. suis, relative to H. pylori, in gastric biopsies of patients with idiopathic parkinsonism (IP) and controls from gastroenterology services.
methodsDNA extracts, archived at a Helicobacter Reference Laboratory, from IP patient and gastroenterology service biopsies were examined anonymously for H. suis, using species-specific RT-PCR.
resultsRelative risk of having H. suis in 60 IP patients compared with 256 controls was 10 times greater than that of having H. pylori. In patients with IP and controls, respectively, frequencies of H. suis were 27 (exact binomial 95% C.I. 15, 38) and 2 (0, 3)%, and of H. pylori, 28 (17, 40) and 16 (12, 21)%. Excess of H. suis in IP held when only the antral or corporal biopsy was considered. Of 16 IP patients with H. suis, 11 were from 19 with proven H. pylori eradication, 3 from 17 pre-H. pylori eradication, 2 from 24 H. pylori culture/PCR-negative. Frequency was different between groups (P = 0.001), greatest where H. pylori had been eradicated. Even without known exposure to anti-H. pylori therapy, H. suis was more frequent in IP patients (5/41) than in controls (1/155) (P = 0.002). Partial multilocus sequence typing confirmed that strains from IP patients (6) and control (1) differed from RT-PCR standard strain.
conclusionsGreater frequency of H. suis in idiopathic parkinsonism appears exaggerated following H. pylori eradication. Multilocus sequence testing comparison with porcine strains may clarify whether transmission is from pigs/porcine products or of human-adapted, H. suis-like, bacteria.
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