ArticleScandinavian journal of immunology2014
Fc gamma receptor IIa-H131R polymorphism and malaria susceptibility in sympatric ethnic groups, Fulani and Dogon of Mali.
Article in Scandinavian journal of immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 29 citations in OpenAlex.
- An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2025Article
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- Fc Gamma Receptor IIIB NA1/NA2/SH Polymorphisms Are Associated with Malaria Susceptibility and Antibody Levels toInternational journal of molecular sciences · 2022Article
- Review
- Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria.PLoS neglected tropical diseases · 2021Article
- Genetic variation in the immune system and malaria susceptibility in infants: a nested case-control study in Nanoro, Burkina Faso.Malaria journal · 2021Article
- Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.Scientific reports · 2021Article
- What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?Scandinavian journal of immunology · 2020Review
- Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population.Frontiers in immunology · 2020Review
- Susceptibility toFrontiers in immunology · 2020Article
- HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells.The Journal of clinical investigation · 2017Article
- Malaria prevalence, prevention and treatment seeking practices among nomadic pastoralists in northern Senegal.Malaria journal · 2017Article
- Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria.eLife · 2017Article
- Article
- Plasmodium falciparum malaria parasitaemia among indigenous Batwa and non-indigenous communities of Kanungu district, Uganda.Malaria journal · 2016Article
- Article
- Do advanced glycation end-products play a role in malaria susceptibility?Parasite (Paris, France) · 2016Review
- Alloantibody Generation and Effector Function Following Sensitization to Human Leukocyte Antigen.Frontiers in immunology · 2016Review
- Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.Malaria journal · 2015Article
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and the Dogon. The lower susceptibility to Plasmodium falciparum malaria seen in the Fulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S (HbS), haemoglobin C (HbC), alpha-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Given the observed differences in the distribution of FcγRIIa allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274-R131H polymorphism in the FcγRIIa gene in a study of Dogon and Fulani in Mali (n = 939). We confirm that the Fulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total IgG antibodies (anti-CSP, anti-AMA1, anti-MSP1 and anti-MSP2) and more total IgE (P < 0.05) compared with the Dogon ethnic group. Furthermore, the Fulani exhibit higher frequencies of the blood group O (56.5%) compared with the Dogon (43.5%) (P < 0.001). With regard to the FcγRIIa polymorphism and allele frequency, the Fulani group have a higher frequency of the H allele (Fulani 0.474, Dogon 0.341, P < 0.0001), which was associated with greater total IgE production (P = 0.004). Our findings show that the FcγRIIa polymorphism might have an implication in the relative protection seen in the Fulani tribe, with confirmatory studies required in other malaria endemic settings.
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