Evidence map›Paper›PMID 24117648›Full record

ReviewAnnals of the New York Academy of Sciences2013

Physiology of the upper segment, body, and lower segment of the esophagus.

Larry Miller, Pere Clavé, Ricard Farré, Begoña Lecea, Michael R Ruggieri, Ann Ouyang, Julie Regan, Barry P McMahon

Erratum issuedAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Phase concept: Novel dynamic endoscopic assessment of intramural antireflux mechanisms (with video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Dysphagia: current reality and scope of the problem.Nature reviews. Gastroenterology & hepatology · 2015
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Larry MillerNorth Shore Long Island Jewish Medical Center, New Hyde Park, New York.
Pere ClavéCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain.
Ricard FarréCenter for Gastroenterological Research, Catholic University, Leuven, Belgium.
Begoña LeceaLaboratori de Fisiologia Digestiva, Hospital de Mataró, Mataró, Spain.
Michael R RuggieriDepartment of Anatomy and Cell Biology, Temple University, Philadelphia, Pennsylvania.
Ann OuyangPenn State College of Medicine, Hershey, Pennsylvania.
Julie ReganTrinity Academic Gastroenterology Group, Tallaght Hospital, Dublin, Ireland.
Barry P McMahonTrinity Academic Gastroenterology Group, Tallaght Hospital, Dublin, Ireland.

Funding

Gastroesophageal Antireflux MechanismsR01DK079954 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI MILLER, LARRY S, RUGGIERI, MICHAEL RAYMOND · 2010 to 2013
$1.3M
NIDDK NIH HHS R01 DK079954
6 · The paper itself

Abstract

The following discussion on the physiology of the esophagus includes commentaries on the function of the muscularis mucosa and submucosa as a mechanical antireflux barrier in the esophagus; the different mechanisms of neurological control in the esophageal striated and smooth muscle; new insights from animal models into the neurotransmitters mediating lower esophageal sphincter (LES) relaxation, peristalsis in the esophageal body (EB), and motility of esophageal smooth muscle; differentiation between in vitro properties of the lower esophageal circular muscle, clasp muscle, and sling fibers; alterations in the relationship between pharyngeal contraction and relaxation of the upper esophageal sphincter (UES) in patients with dysphagia; the mechanical relationships between anterior hyoid movement, the extent of upper esophageal opening, and aspiration; the application of fluoroscopy and manometry with biomechanics to define the stages of UES opening; and nonpharmacological approaches to alter the gastroesophageal junction (GEJ).

Indexed as

Esophagogastric JunctionEsophagusHumansMucous MembraneMuscle, SmoothPeristalsisesophagusGERDlower esophageal segmentmuscularis mucosasmooth musclesubmucosaupper esophageal segment

Identifiers

PMID24117648
PMCPMC3889860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.