Trial reportActa psychiatrica Scandinavica2014
Medication adherence in a comparative effectiveness trial for bipolar disorder.
Trial report in Acta psychiatrica Scandinavica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Drug adherence attitude in patients with bipolar disorder and unipolar depression: Insights from a cross-sectional study in central India.Journal of family medicine and primary care · 2025Article
- Impact of Lithium on Suicidality in the Veteran Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022Article
- Prevalence of Suicidality and its Association with Quality of Life in Older Patients with Clinically Stable Psychiatric Disorders in China During the COVID-19 Pandemic.Journal of geriatric psychiatry and neurology · 2022Article
- Article
- Case Report: Paliperidone Palmitate in the Management of Bipolar I Disorder With Non-compliance.Frontiers in psychiatry · 2020Article
- Identifying clinical net benefit of psychotropic medication use with latent variable techniques: Evidence from Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).Journal of affective disorders · 2018Article
- Treatment of Bipolar Disorder in a Lifetime Perspective: Is Lithium Still the Best Choice?Clinical drug investigation · 2017Review
- Treatment-adherence in bipolar disorder: A patient-centred approach.World journal of psychiatry · 2016Review
- Lithium in Bipolar Disorder: Optimizing Therapy Using Prolonged-Release Formulations.Drugs in R&D · 2016Review
- Long-Acting Injectable Antipsychotics for Prevention of Relapse in Bipolar Disorder: A Systematic Review and Meta-Analyses of Randomized Controlled Trials.The international journal of neuropsychopharmacology · 2016Article
- Unmet needs of bipolar disorder patients.Neuropsychiatric disease and treatment · 2016Review
- Symptom severity, self-reported adherence, and electronic pill monitoring in poorly adherent patients with bipolar disorder.Bipolar disorders · 2015Article
- Compliance as a stable function in the treatment course of bipolar disorder in patients stabilized on olanzapine: results from a 24-month observational study.International journal of bipolar disorders · 2014Article
- Results from an online survey of patient and caregiver perspectives on unmet needs in the treatment of bipolar disorder.The primary care companion for CNS disorders · 2014Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectivePsychopharmacology remains the foundation of treatment for bipolar disorder, but medication adherence in this population is low (range 20-64%). We examined medication adherence in a multisite, comparative effectiveness study of lithium.
methodThe Lithium Moderate Dose Use Study (LiTMUS) was a 6-month, six-site, randomized effectiveness trial of adjunctive moderate dose lithium therapy compared with optimized treatment in adult out-patients with bipolar I or II disorder (N=283). Medication adherence was measured at each study visit with the Tablet Routine Questionnaire.
resultsWe found that 4.50% of participants reported missing at least 30% of their medications in the past week at baseline and non-adherence remained low throughout the trial (<7%). Poor medication adherence was associated with more manic symptoms and side-effects as well as lower lithium serum levels at mid- and post-treatment, but not with poor quality of life, overall severity of illness, or depressive symptoms.
conclusionParticipants in LiTMUS were highly adherent with taking their medications. The lack of association with possible predictors of adherence, such as depression and quality of life, could be explained by the limited variance or other factors as well as by not using an objective measure of adherence.
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