ArticleJournal of the American Chemical Society2013
Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges.Angewandte Chemie (International ed. in English) · 2026Review
- Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities.Chembiochem : a European journal of chemical biology · 2025Review
- Synthesis and characterization of coumarin-derived sulfur analogues using Lawesson's reagent.Acta crystallographica. Section C, Structural chemistry · 2025Article
- Review
- Multi-Photon-Sensitive Chromophore for the Photorelease of Biologically Active Phenols.ACS chemical neuroscience · 2023Article
- Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth.Chemical science · 2023Article
- Orthogonal Light-Activated DNA for Patterned Biocomputing within Synthetic Cells.Journal of the American Chemical Society · 2023Article
- Light-Activated Translation of Different mRNAs in Cells via Wavelength-Dependent Photouncaging.Angewandte Chemie (International ed. in English) · 2023Article
- Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using enzymatic fusion proteins.Chemical science · 2023Article
- A photocaged orexin-B for spatiotemporally precise control of orexin signaling.Cell chemical biology · 2022Article
- Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology.Nature communications · 2022Article
- Oxime as a general photocage for the design of visible light photo-activatable fluorophores.Chemical science · 2021Article
- Neural and behavioral control inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Light-Controlled Cell-Cycle Arrest and Apoptosis.Angewandte Chemie (International ed. in English) · 2021Article
- Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.Chemical reviews · 2020Article
- Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties.Molecules (Basel, Switzerland) · 2020Article
- Conditionally Activatable Visible-Light Photocages.Journal of the American Chemical Society · 2020Article
- Green light triggered [2+2] cycloaddition of halochromic styrylquinoxaline-controlling photoreactivity by pH.Nature communications · 2020Article
- Useful Caged Compounds for Cell Physiology.Accounts of chemical research · 2020Article
- Water-Soluble BODIPY Photocages with Tunable Cellular Localization.Journal of the American Chemical Society · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Caged compounds are molecules rendered functionally inert by derivatization with a photochemical protecting group. We describe the design logic behind the development of a diethylaminocoumarin (DEAC) caging chromophore, DEAC450, that absorbs blue light strongly (ε450 = 43,000 M(-1) cm(-1)) and violet light 11-fold more weakly. The absorption minimum is in the wavelength range (340-360 nm) that is traditionally used for photolysis of many widely used nitroaromatic caged compounds (e.g., 4-carboxymethoxy-5,7-dinitroindolinyl(CDNI)-GABA). We used this chromophore to synthesize DEAC450-caged cAMP and found this probe was very stable toward aqueous hydrolysis in the electronic ground state but was photolyzed with a quantum efficiency of 0.78. When DEAC450-cAMP and CDNI-GABA where co-applied to striatal cholinergic interneurons, the caged compounds were photolyzed in an chromatically orthogonal manner using blue and violet light so as to modulate the neuronal firing rate in a bidirectional way.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.