ArticleBritish journal of haematology2014
Single nucleotide polymorphism array analysis of bone marrow failure patients reveals characteristic patterns of genetic changes.
Article in British journal of haematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Somatic mutations in CSK disrupt immune regulation in a Chinese aplastic anemia cohort.Communications biology · 2026Article
- Review
- Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities.JCI insight · 2022Article
- The clinical and laboratory evaluation of patients with suspected hypocellular marrow failure.Hematology. American Society of Hematology. Education Program · 2021Review
- The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis.Blood advances · 2021Article
- Clinical Applications of Chromosomal Microarray Testing in Myeloid Malignancies.Current hematologic malignancy reports · 2020Review
- Acquired Aplastic Anemia as a Clonal Disorder of Hematopoietic Stem Cells.Stem cell reviews and reports · 2020Review
- A brief, but comprehensive, guide to clonal evolution in aplastic anemia.Hematology. American Society of Hematology. Education Program · 2018Review
- Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications.Blood advances · 2017Article
- Recent advances in understanding clonal haematopoiesis in aplastic anaemia.British journal of haematology · 2017Review
- Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults.Leukemia & lymphoma · 2016Article
- Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia.Cancer genetics · 2015Article
- Acquired aplastic anemia in children.Pediatric clinics of North America · 2013Review
- Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
The bone marrow failure syndromes (BMFS) are a heterogeneous group of rare blood disorders characterized by inadequate haematopoiesis, clonal evolution, and increased risk of leukaemia. Single nucleotide polymorphism arrays (SNP-A) have been proposed as a tool for surveillance of clonal evolution in BMFS. To better understand the natural history of BMFS and to assess the clinical utility of SNP-A in these disorders, we analysed 124 SNP-A from a comprehensively characterized cohort of 91 patients at our BMFS centre. SNP-A were correlated with medical histories, haematopathology, cytogenetic and molecular data. To assess clonal evolution, longitudinal analysis of SNP-A was performed in 25 patients. We found that acquired copy number-neutral loss of heterozygosity (CN-LOH) was significantly more frequent in acquired aplastic anaemia (aAA) than in other BMFS (odds ratio 12·2, P < 0·01). Homozygosity by descent was most common in congenital BMFS, frequently unmasking autosomal recessive mutations. Copy number variants (CNVs) were frequently polymorphic, and we identified CNVs enriched in neutropenia and aAA. Our results suggest that acquired CN-LOH is a general phenomenon in aAA that is probably mechanistically and prognostically distinct from typical CN-LOH of myeloid malignancies. Our analysis of clinical utility of SNP-A shows the highest yield of detecting new clonal haematopoiesis at diagnosis and at relapse.
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