Evidence map›Paper›PMID 24116689›Full record

ArticleJournal of the American Geriatrics Society2013

Adverse drug events after hospital discharge in older adults: types, severity, and involvement of Beers Criteria Medications.

Abir O Kanaan, Jennifer L Donovan, Nerissa P Duchin, Terry S Field, Jennifer Tjia, Sarah L Cutrona, Shawn J Gagne, Lawrence Garber, Peggy Preusse, Leslie R Harrold and 1 more

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Tools to evaluate medication management for caregivers of people living with dementia: A systematic review.Health expectations : an international journal of public participation in health care and health policy · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Article
  19. Review
  20. Central nervous system medication use around hospitalization.Journal of the American Geriatrics Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Abir O KanaanMCPHS University, Worcester, Massachusetts; Meyers Primary Care Institute, Worcester, Massachusetts; University of Massachusetts Medical School, Worcester, Massachusetts.
Jennifer L Donovan
Nerissa P Duchin
Terry S Field
Jennifer Tjia
Sarah L Cutrona
Shawn J Gagne
Lawrence Garber
Peggy Preusse
Leslie R Harrold
Jerry H Gurwitz
University of Massachusetts Chan Medical School · USMCPHS University · US

Funding

Improving Posthospital Medication Management of Older Adults Through Health ITR18HS017203 · AHRQ · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GURWITZ, JERRY H · 2007 to 2009
$1.2M
University of Massachusetts Center for Clinical and Translational ScienceKL2RR031981 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SULLIVAN, JOHN LEWIS · 2010 to 2011
$1.2M
AHRQ HHS R18 HS017203NCRR NIH HHS KL2 RR031981NCRR NIH HHS KL2RR031981
6 · The paper itself

Abstract

objectivesTo characterize adverse drug events (ADEs) occurring within the high-risk 45-day period after hospitalization in older adults.

designClinical pharmacists reviewed the ambulatory records of 1,000 consecutive discharges.

settingA large multispecialty group practice closely aligned with a Massachusetts-based health plan.

participantsHospitalized individuals aged 65 and older discharged home. MEASUREMENTS: Possible drug-related incidents occurring during the 45-day period after hospitalization were identified and presented to a pair of physician-reviewers who classified incidents as to whether an ADE was present, whether the event was preventable, and the severity of the event. Medications implicated in ADEs were further characterized according to their inclusion in the 2012 Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.

resultsAt least one ADE was identified during the 45-day period in 18.7% (n = 187) of the 1,000 discharges. Of the 242 ADEs identified, 35% (n = 84) were deemed preventable, of which 32% (n = 27) were characterized as serious, and 5% (n = 4) as life threatening. More than half of all ADEs occurred within the first 14 days after hospitalization. The percentage of ADEs in which Beers Criteria medications were implicated was 16.5% (n = 40). Beers criteria medications with both a high quality of evidence and strong strength of recommendation were implicated in 6.6% (n = 16) of the ADEs.

conclusionADEs are common and often preventable in older adults after hospital discharge, underscoring the need to address medication safety during this high-risk period in this vulnerable population. Beers criteria medications played a small role in these events, suggesting that efforts to improve the quality and safety of medication use during this critical transition period must extend beyond a singular focus on Beers criteria medications.

Indexed as

Patient DischargeAgedDrug-Related Side Effects and Adverse ReactionsFemaleHumansInappropriate PrescribingMaleSeverity of Illness IndexTime Factorsadverse drug eventsambulatory care settingBeers medicationsolder adults

Identifiers

PMID24116689
PMCPMC4446728
OpenAlexW2093392191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.