ArticlePloS one2013
A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Protein-Catalyzed Capture Agents.Chemical reviews · 2019Review
- Recent trends in click chemistry as a promising technology for virus-related research.Virus research · 2018Review
- Machine Learning on Signal-to-Noise Ratios Improves Peptide Array Design in SAMDI Mass Spectrometry.Analytical chemistry · 2017Article
- Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications.Biopolymers · 2017Article
- Degradation of Akt using protein-catalyzed capture agents.Journal of peptide science : an official publication of the European Peptide Society · 2016Article
- Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.Journal of the American Chemical Society · 2016Article
- A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.Angewandte Chemie (International ed. in English) · 2015Article
- Epitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin.Angewandte Chemie (International ed. in English) · 2015Article
- A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1.Nature chemistry · 2015Article
- A chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.Angewandte Chemie (International ed. in English) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a method to improve in vitro diagnostic assays that detect immune response, with specific application to HIV-1. The inherent polyclonal diversity of the humoral immune response was addressed by using sequential in situ click chemistry to develop a cocktail of peptide-based capture agents, the components of which were raised against different, representative anti-HIV antibodies that bind to a conserved epitope of the HIV-1 envelope protein gp41. The cocktail was used to detect anti-HIV-1 antibodies from a panel of sera collected from HIV-positive patients, with improved signal-to-noise ratio relative to the gold standard commercial recombinant protein antigen. The capture agents were stable when stored as a powder for two months at temperatures close to 60(o)C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.