ArticlePloS one2013
Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Role and mechanism of ferroptosis in acute lung injury.Cell cycle (Georgetown, Tex.) · 2023Review
- Whole transcriptome analysis reveals that immune infiltration- lncRNAs are related to cellular apoptosis in liver transplantation.Frontiers in immunology · 2023Article
- Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19.Frontiers in pharmacology · 2020Article
- Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation.Cell death & disease · 2019Article
- Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16.BioMed research international · 2019Article
- Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Activation of GABAMediators of inflammation · 2018Article
- Overexpression of Brg1 Alleviates Hepatic Ischemia/Reperfusion-Induced Acute Lung Injury through Antioxidative Stress Effects.Oxidative medicine and cellular longevity · 2017Article
- Protective effect of eNOS overexpression against ischemia/reperfusion injury in small-for-size liver transplantation.Experimental and therapeutic medicine · 2016Article
- Propofol attenuated liver transplantation-induced acute lung injury via connexin43 gap junction inhibition.Journal of translational medicine · 2016Article
- Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats.Journal of translational medicine · 2016Article
- Intestinal injury following liver transplantation was mediated by TLR4/NF-κB activation-induced cell apoptosis.Molecular medicine reports · 2016Article
- The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice.Influenza and other respiratory viruses · 2016Article
- Mast cells in the colon of Trypanosoma cruzi-infected patients: are they involved in the recruitment, survival and/or activation of eosinophils?Parasitology research · 2015Article
- Effects of ischemic preconditioning in a pig model of large-for-size liver transplantation.Clinics (Sao Paulo, Brazil) · 2015Article
- Downregulation of Lung Toll-Like Receptor 4 Could Effectively Attenuate Liver Transplantation-Induced Pulmonary Damage at the Early Stage of Reperfusion.Mediators of inflammation · 2015Article
- Oxidative Stress-Mediated Reperfusion Injury 2014.Oxidative medicine and cellular longevity · 2015Article
- Impact of recombinant globular adiponectin on early warm ischemia-reperfusion injury in rat bile duct after liver transplantation.Scientific reports · 2014Article
- Gypenoside attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative and anti-apoptotic bioactivities.Experimental and therapeutic medicine · 2014Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. Amplified inflammatory response after transplantation contributes to the process of ALI, but the mechanism underlying inflammation activation is not completely understood. We have demonstrated that mast cell stabilization attenuated inflammation and ALI in a rodent intestine ischemia/reperfusion model. We hypothesized that upregulation of inflammation triggered by mast cell activation may be involve in ALI after liver transplantation.
methodsAdult male Sprague-Dawley rats received orthotopic autologous liver transplantation (OALT) and were executed 4, 8, 16, and 24 h after OALT. The rats were pretreated with the mast cell stabilizers cromolyn sodium or ketotifen 15 min before OALT and executed 8 h after OALT. Lung tissues and arterial blood were collected to evaluate lung injury. β-hexosaminidase and mast cell tryptase levels were assessed to determine the activation of mast cells. Tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6 in serum and lung tissue were analyzed by enzyme-linked immunosorbent assay. Nuclear factor-kappa B (NF-κB) p65 translocation was assessed by Western blot.
resultsThe rats that underwent OALT exhibited severe pulmonary damage with a high wet-to-dry ratio, low partial pressure of oxygen, and low precursor surfactant protein C levels, which corresponded to the significant elevation of pro-inflammatory cytokines, β-hexosaminidase, and tryptase levels in serum and lung tissues. The severity of ALI progressed and maximized 8 h after OALT. Mast cell stabilization significantly inhibited the activation of mast cells, downregulated pro-inflammatory cytokine levels and translocation of NF-κB, and attenuated OALT-induced ALI.
conclusionsMast cell activation amplified inflammation and played an important role in the process of post-OALT related ALI.
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