ArticlePloS one2013
Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Age-Related Changes in SerumBiomolecules · 2023Article
- Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome.Journal of Crohn's & colitis · 2023Article
- Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles.Scientific reports · 2022Article
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- Glycan Imaging Mass Spectrometry: Progress in Developing Clinical Diagnostic Assays for Tissues, Biofluids, and Cells.Clinics in laboratory medicine · 2021Review
- Glycosylation and Aging.Advances in experimental medicine and biology · 2021Article
- Decoding the language of microbiomes using word-embedding techniques, and applications in inflammatory bowel disease.PLoS computational biology · 2020Article
- IgG Glycosylation Profile and the Glycan Score Are Associated with Type 2 Diabetes in Independent Chinese Populations: A Case-Control Study.Journal of diabetes research · 2020Article
- Identification of serum N-glycoproteins as a biological correlate underlying chronic stress response in mice.Molecular biology reports · 2019Article
- Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice.Glycoconjugate journal · 2018Article
- Stage Dependence, Cell-Origin Independence, and Prognostic Capacity of Serum Glycan Fucosylation, β1-4 Branching, β1-6 Branching, and α2-6 Sialylation in Cancer.Journal of proteome research · 2018Article
- Behavior of blood plasma glycan features in bladder cancer.PloS one · 2018Article
- Promoter methylation of theClinical epigenetics · 2018Article
- Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.Diabetologia · 2017Article
- Serum Aberrant N-Glycan Profile as a Marker Associated with Early Antibody-Mediated Rejection in Patients Receiving a Living Donor Kidney Transplant.International journal of molecular sciences · 2017Article
- Intact glycopeptide characterization using mass spectrometry.Expert review of proteomics · 2016Review
- Fetal Environment and Glycosylation Status in Neonatal Cord Blood: A Comprehensive Mass Spectrometry-based Glycosylation Analysis.Medicine · 2016Article
- Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.Inflammatory bowel diseases · 2015Article
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were to determine the change of whole-serum N-glycan profile in ulcerative colitis (UC) patients and to investigate its clinical utility.
methodsWe collected serum from 75 UC patients at the time of admission and the same number of age/sex-matched healthy volunteers. Serum glycan profile was measured by comprehensive quantitative high-throughput glycome analysis and was compared with disease activity and prognosis.
resultsOut of 61 glycans detected, 24 were differentially expressed in UC patients. Pathway analysis demonstrated that highly sialylated multi-branched glycans and agalactosyl bi-antennary glycans were elevated in UC patients; in addition, the glycan ratio m/z 2378/1914, which also increased in UC, showed the highest Area under Receiver Operating Characteristic curve (0.923) for the diagnosis of UC. Highly sialylated multi-branched glycans and the glycan ratio m/z 2378/1914 were higher in the patients with total colitis, Clinical Activity Index >10, Mayo endoscopic score 3, or a steroid-refractory status. In particular, the glycan ratio m/z 2378/1914 (above median) was an independent prognostic factor for the need for an operation (hazard ratio, 2.67; 95% confidence interval, 1.04-7.84).
conclusionsWhole-serum glycan profiles revealed that the glycan ratio m/z 2378/1914 and highly sialylated multi-branched glycans increase in UC patients, and are correlated with disease activity. The glycan ratio m/z 2378/1914 was an independent predictive factor of the prognosis of UC.
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