ReviewJournal of the American Society of Nephrology : JASN2013
Obesity in CKD--what should nephrologists know?
Review in Journal of the American Society of Nephrology : JASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06433388 (Perirenal Fats of Chronic Kidney Disease in Patients With Fatty Liver Disease.), which is not on this map. Cited by 114 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perirenal Fats of Chronic Kidney Disease in Patients With Fatty Liver Disease.
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 229 citations in OpenAlex.
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.PloS one · 2018Pooled it
- Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial.Journal of the American Society of Nephrology : JASN · 2018Trial
- The "obesity paradox" in dosing: a comprehensive analytical review of cockcroft-gault versus CKD-EPI for predicting clearance of narrow-therapeutic-index drugs in patients with BMI > 40 kg/m².European journal of clinical pharmacology · 2026Review
- Associations of Body Composition Biomarkers with Survival, Cardiovascular Events, and Progression in Persons with Chronic Kidney Disease: Insights from the Renal Risk in Derby Study.American journal of nephrology · 2026Article
- Association of anthropometric and biochemical-anthropometric obesity indices with chronic kidney disease in diabetes: a KNHANES-based study.Clinical and experimental nephrology · 2026Article
- Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts.Animal models and experimental medicine · 2026Article
- Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.Molecular therapy. Nucleic acids · 2026Article
- Article
- Age-Stratified Associations of Sarcopenic Obesity With Mortality in Type 2 Diabetes.Journal of cachexia, sarcopenia and muscle · 2026Article
- Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study.Kidney research and clinical practice · 2026Article
- Prognostic Value of Vascular Calcification in Long-Term Outcomes in Obese and Non-Obese Patients with Chronic Kidney Disease.Journal of cardiovascular development and disease · 2025Article
- Trends in Cardiovascular Mortality in Patients With Chronic Kidney Disease From 1999 to 2020: A Retrospective Study in the United States.Clinical cardiology · 2025Article
- Impact of Sarcopenia, Dynapenia, and Obesity on Muscle Strength and Quality in Chronic Kidney Disease Patients: A Sex-Specific Study.Healthcare (Basel, Switzerland) · 2025Article
- Association of changes in metabolic syndrome with new-onset and progression of chronic kidney disease.Endocrine · 2025Article
- Plant-Based Diets across the Spectrum of Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Role of obesity in chronic kidney disease progression.Current research in physiology · 2025Review
- Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders.Frontiers in endocrinology · 2025Review
- One anastomosis gastric bypass ameliorates diabetic nephropathy via regulating the GLP-1-mediated Sirt1/AMPK/PGC1α pathway.Clinical and experimental nephrology · 2024Article
- Article
- Body mass index modifies the effect of urinary protein-to-creatinine ratio on chronic kidney disease progression.International urology and nephrology · 2024Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Obesity, the epidemic of the 21st century, carries a markedly increased risk for comorbid complications, such as type 2 diabetes, cancer, hypertension, dyslipidemia, cardiovascular disease, and sleep apnea. In addition, obesity increases the risk for CKD and its progression to ESRD. Paradoxically, even morbid obesity associates with better outcomes in studies of ESRD patients on maintenance dialysis. Because the number of obese CKD and maintenance dialysis patients is projected to increase markedly in developed as well as low- and middle-income countries, obesity is a rapidly emerging problem for the international renal community. Targeting the obesity epidemic represents an unprecedented opportunity for health officials to ameliorate the current worldwide increase in CKD prevalence. Nephrologists need more information about assessing and managing obesity in the setting of CKD. Specifically, more precise estimation of regional fat distribution and the amount of muscle mass should be introduced into regular clinical practice to complement more commonly used practical markers, such as body mass index. Studies examining the effects of obesity on kidney disease progression and other clinical outcomes along with weight management strategies are much needed in this orphan area of research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.