ArticleJournal of magnetic resonance imaging : JMRI2014
Optimized simultaneous ASL and BOLD functional imaging of the whole brain.
Article in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge.PloS one · 2020Trial
- FMRI Approaches to Mapping Cerebrovascular Reactivity: Comparison of Gradient Echo BOLD and Spin Echo BOLD With Arterial Spin Labeling.Magnetic resonance in medicine · 2026Article
- Relationships between cerebral blood flow and cognition in young adults born very preterm and at term.Scientific reports · 2026Article
- WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis.Scientific data · 2025Article
- Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging.Scientific reports · 2025Article
- Breath-hold calibrated fMRI mapping of absolute cerebral metabolic rate of oxygen metabolism (CMROImaging neuroscience (Cambridge, Mass.) · 2024Article
- Evidence for a sustained cerebrovascular response following motor practice.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease.Metabolites · 2022Article
- Cerebral oxygen extraction fraction MRI: Techniques and applications.Magnetic resonance in medicine · 2022Review
- The effect of acquisition duration on cerebral blood flow-based resting-state functional connectivity.Human brain mapping · 2022Article
- HyperpolarizedMagnetic resonance in medicine · 2022Review
- A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMROJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Comparison of test-retest reliability of BOLD and pCASL fMRI in a two-center study.BMC medical imaging · 2022Article
- Impaired Cerebrovascular Reactivity in Huntington's Disease.Frontiers in physiology · 2021Article
- Identifying psychosis spectrum youth using support vector machines and cerebral blood perfusion as measured by arterial spin labeled fMRI.NeuroImage. Clinical · 2020Article
- Recent progress in ASL.NeuroImage · 2019Review
- Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity.NeuroImage · 2019Article
- Article
- Multiband multi-echo imaging of simultaneous oxygenation and flow timeseries for resting state connectivity.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo compare a double-excitation combined arterial-spin labeling/blood-oxygenation level dependent (ASL/BOLD) functional imaging method to a double-echo method. ASL provides a useful complement to standard BOLD functional imaging, to map effects of cerebral hemodynamics. Whole-brain imaging is necessary to properly characterize large functional networks. A challenge of whole-brain ASL/BOLD is that images for ASL functional contrast must be acquired before significant longitudinal relaxation of the inverted spins occurs; however, a longer echo time (TE) is required for optimal BOLD functional contrast, lengthening the acquisition time. Thus, existing combined ASL/BOLD studies have only partial-brain coverage. MATERIALS AND
methodsThe proposed method allows acquisition of images for ASL contrast within a short period after the ASL labeling pulse and postinversion delay, then subsequent acquisition of images with longer TE for BOLD contrast. The technique is demonstrated using a narrative comprehension task in 35 normal children, and the double-excitation method is empirically compared with the double-echo method in 7 normal adults.
resultsCompared with a double-echo sequence, simulations show the double-excitation method improves ASL contrast-to-noise ratio (CNR) (∼50%) in later-acquired slices with minimal (<1%) reduction in BOLD CNR in earlier-acquired slices if reduced excitation flip angles for the ASL acquisitions are used. Empirical results from adult data are in agreement with the simulations. Group analyses from the narrative comprehension task also show greater intersubject sensitivity in BOLD versus ASL.
conclusionOur method simultaneously optimizes ASL and BOLD acquisitions for CNR while economizing acquisition time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.