ArticleJournal of biomedical materials research. Part A2014
Toll-like receptors-2 and 4 are overexpressed in an experimental model of particle-induced osteolysis.
Article in Journal of biomedical materials research. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The use of bone turnover markers for monitoring the treatment of osteoporosis in postmenopausal females undergoing total knee arthroplasty: a prospective randomized study.Journal of orthopaedic surgery and research · 2021Trial
- Association of CXCL16 in aseptic loosening following total hip arthroplasty and its effect on bone metabolism: a case-control study.Annals of medicine · 2025Article
- Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis.Current osteoporosis reports · 2022Review
- The Expression Levels of Toll-like Receptors after Metallic Particle and Ion Exposition in the Synovium of a Murine Model.Journal of clinical medicine · 2021Article
- circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.International journal of medical sciences · 2021Article
- Diagnosis and management of implant debris-associated inflammation.Expert review of medical devices · 2020Review
- Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment.Journal of clinical medicine · 2019Review
- Cytokine Profile in Patients with Aseptic Loosening of Total Hip Replacements and Its Relation to Metal Release and Metal Allergy.Journal of clinical medicine · 2019Article
- The biological response to orthopedic implants for joint replacement. II: Polyethylene, ceramics, PMMA, and the foreign body reaction.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Review
- Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements.Journal of orthopaedic translation · 2017Article
- The Biologic Response to Bearing Materials.Orthopaedic knowledge online · 2016Article
- Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing.Regenerative engineering and translational medicine · 2016Article
- Aging, inflammation, stem cells, and bone healing.Stem cell research & therapy · 2016Review
- Innate Immunity and Biomaterials at the Nexus: Friends or Foes.BioMed research international · 2015Review
- Interaction of Materials and Biology in Total Joint Replacement - Successes, Challenges and Future Directions.Journal of materials chemistry. B · 2014Article
- Bone and the innate immune system.Current osteoporosis reports · 2014Review
- Innate immunity sensors participating in pathophysiology of joint diseases: a brief overview.Journal of long-term effects of medical implants · 2014Article
- Innate immune reactions in septic and aseptic osteolysis around hip implants.Journal of long-term effects of medical implants · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Aseptic loosening secondary to particle-associated periprosthetic osteolysis remains a major cause of failure of total joint replacements (TJR) in the mid- and long term. As sentinels of the innate immune system, macrophages are central to the recognition and initiation of the inflammatory cascade, which results in the activation of bone resorbing osteoclasts. Toll-like receptors (TLRs) are involved in the recognition of pathogen-associated molecular patterns and danger-associated molecular patterns. Experimentally, polymethylmethacrylate and polyethylene (PE) particles have been shown to activate macrophages via the TLR pathway. The specific TLRs involved in PE particle-induced osteolysis remain largely unknown. We hypothesized that TLR-2, -4, and -9 mediated responses play a critical role in the development of PE wear particle-induced osteolysis in the murine calvarium model. To test this hypothesis, we first demonstrated that PE particles caused observable osteolysis, visible by microCT and bone histomorphometry when the particles were applied to the calvarium of C57BL/6 mice. The number of TRAP positive osteoclasts was significantly greater in the PE-treated group when compared to the control group without particles. Finally, using immunohistochemistry, TLR-2 and TLR-4 were highly expressed in PE particle-induced osteolytic lesions, whereas TLR-9 was downregulated. TLR-2 and -4 may represent novel therapeutic targets for prevention of wear particle-induced osteolysis and accompanying TJR failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.