ArticleHead & neck2014
p16 status, pathologic and clinical characteristics, biomolecular signature, and long-term outcomes in head and neck squamous cell carcinomas of unknown primary.
Article in Head & neck, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review.Clinical & experimental metastasis · 2015Pooled it
- Combined Assessment of HPV and p16 Optimizes Clinical Decision-Making in Head and Neck Cancer of Unknown Primary.Cancer medicine · 2026Article
- Efficacy of Multimodal Work-Up of Head and Neck Squamous Cell Carcinoma Lymph Node Metastasis of Unknown Primary.Head & neck · 2026Article
- Article
- Predictors for Success and Failure in Transoral Robotic Surgery-A Retrospective Study in the North of the Netherlands.Cancers · 2024Article
- A comparison between p16-positive head and neck cancer of unknown primary (HPV-HNCUP) and oropharyngeal squamous cell carcinoma (HPV-OPSCC): are they the same disease?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Survival Outcome in True Carcinoma of Unknown Primary (tCUP) with p16 + Cervical Metastasis.International archives of otorhinolaryngology · 2023Article
- Cancer of unknown primary site in the mandibular region: A case report.Oncology letters · 2023Article
- Understanding the Role of Human Papillomavirus in Head and Neck Cancer of Unknown Primary: A Systematic Review.Cureus · 2023Review
- A Systematic Review of Diagnostic and Prognostic Biomarkers for Head and Neck Cancer of Unknown Primary: An Unmet Clinical Need.Diagnostics (Basel, Switzerland) · 2023Review
- The Added Value ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Factors Influencing the Outcome of Head and Neck Cancer of Unknown Primary (HNCUP).Journal of clinical medicine · 2022Article
- Cervical squamous cell carcinoma of unknown primary: Oncological outcomes and prognostic factors.Frontiers in oncology · 2022Article
- Article
- Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival.International archives of otorhinolaryngology · 2021Article
- Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features.Iranian journal of medical sciences · 2021Article
- Treatment of head and neck carcinoma of unknown primary: Cracking a nut with a sledgehammer?Laryngoscope investigative otolaryngology · 2021Article
- Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry.Annals of translational medicine · 2021Article
- Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck.Current treatment options in oncology · 2020Review
- Predictors of survival and recurrence after primary surgery for cervical metastasis of unknown primary.Journal of cancer research and clinical oncology · 2020Observational
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe purpose of this study was to report associations between p16 status, clinicopathologic characteristics, and outcomes for head and neck squamous cell carcinoma of unknown primary (CUP).
methodsSpecimens of squamous cell CUP were reanalyzed. Human papillomavirus (HPV) status was determined by p16 stain. A tissue microarray (TMA) was constructed to evaluate biomarkers potentially prognostic in head and neck squamous cell carcinoma (HNSCC).
resultsA majority of the population (n = 26; 74%) was p16 positive (+). Prognostic factors benefiting survival were p16+ status (p < .0001), absence of macroscopic extracapsular extension (ECE; p = .004), younger age (p = .01), and higher grade (p = 0.007). The prognostic implication of worse overall survival (OS) with macroscopic ECE (p = .009) remained significant when limited to patients who were p16+ (p = .002). Exploratory TMA between unknown primary and controls suggested a biomolecular difference between squamous cell CUP and known-primary cancer.
conclusionThe majority of patients with squamous cell CUP were p16+, indicative of HPV association. P16 staining and ECE seem to be the most prognostic features in squamous cell CUP.
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