ArticleThe Journal of comparative neurology2014
Natural and lesion-induced decrease in cell proliferation in the medial nucleus of the trapezoid body during hearing development.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex.Frontiers in cellular neuroscience · 2025Article
- Astrocyte ensheathment of calyx-forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes.The Journal of comparative neurology · 2024Article
- Long-term microglia depletion impairs synapse elimination and auditory brainstem function.Scientific reports · 2022Article
- Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body.Frontiers in integrative neuroscience · 2022Review
- Distinct Cellular Profiles ofBrain sciences · 2021Article
- Axon-glia interactions in the ascending auditory system.Developmental neurobiology · 2021Review
- Two types of somatic spines provide sites for intercellular signaling during calyx of Held growth and maturation.Synapse (New York, N.Y.) · 2021Article
- Auditory brainstem development and plasticity.Current opinion in physiology · 2020Article
- Impacts of trace metals on African common toad,Heliyon · 2020Article
- Article
- Follow-up study of subventricular zone progenitors with multiple rounds of cell division during sulcogyrogenesis in the ferret cerebral cortex.IBRO reports · 2019Article
- Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem.Frontiers in neural circuits · 2019Article
- Glial Cell Expansion Coincides with Neural Circuit Formation in the Developing Auditory Brainstem.Developmental neurobiology · 2018Article
- Myelin development, plasticity, and pathology in the auditory system.Developmental neurobiology · 2018Review
- Photon Entanglement Through Brain Tissue.Scientific reports · 2016Article
- Glial Cell Contributions to Auditory Brainstem Development.Frontiers in neural circuits · 2016Review
- Distribution of glial cells in the auditory brainstem: normal development and effects of unilateral lesion.Neuroscience · 2014Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The functional interactions between neurons and glial cells that are important for nervous system function are presumably established during development from the activity of progenitor cells. In this study we examined proliferation of progenitor cells in the medial nucleus of the trapezoid body (MNTB) located in the rat auditory brainstem. We performed DNA synthesis labeling experiments to demonstrate changes in cell proliferation activity during postnatal stages of development. An increase in cell proliferation correlated with MNTB growth and the presence of S100β-positive astrocytes among MNTB neurons. In additional experiments we analyzed the fate of newly born cells. At perinatal ages, newly born cells colabeled with the astrocyte marker S100β in higher numbers than when cells were generated at postnatal day 6. Furthermore, we identified newly born cells that were colabeled with caspase-3 immunohistochemistry and performed comparative experiments to demonstrate that there is a natural decrease in cell proliferation activity during postnatal development in rats, mice, gerbils, and ferrets. Lastly, we found that there is a stronger decrease in MNTB cell proliferation after performing bilateral lesions of the auditory periphery in rats. Altogether, these results identify important stages in the development of astrocytes in the MNTB and provide evidence that the proliferative activity of the progenitor cells is developmentally regulated. We propose that the developmental reduction in cell proliferation may reflect coordinated signaling between the auditory brainstem and the auditory periphery.
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