ArticleChemistry (Weinheim an der Bergstrasse, Germany)2013
Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Enantioselective Cytotoxicity of Chiral Diphosphine Ruthenium(II) Complexes Against Cancer Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity.Inorganic chemistry frontiers · 2022Article
- Synthesis, Characterization, and Antiproliferative Activity of Novel Chiral [QuinoxP*AuClMolecules (Basel, Switzerland) · 2020Article
- Intracellular Photophysics of an Osmium Complex bearing an Oligothiophene Extended Ligand.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Anti-inflammatory activity of electron-deficient organometallics.Royal Society open science · 2017Article
- Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents.Journal of inorganic biochemistry · 2016Article
- Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Hydrogen bonding and anticancer properties of water-soluble chiralEuropean journal of inorganic chemistry · 2015Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Four chiral Os(II) arene anticancer complexes have been isolated by fractional crystallization. The two iodido complexes, (S(Os),S(C))-[Os(η(6)-p-cym)(ImpyMe)I]PF6 (complex 2, (S)-ImpyMe: N-(2-pyridylmethylene)-(S)-1-phenylethylamine) and (R(Os),R(C))-[Os(η(6)-p-cym)(ImpyMe)I]PF6 (complex 4, (R)-ImpyMe: N-(2-pyridylmethylene)-(R)-1-phenylethylamine), showed higher anticancer activity (lower IC50 values) towards A2780 human ovarian cancer cells than cisplatin and were more active than the two chlorido derivatives, (S(Os),S(C))-[Os(η(6)-p-cym)(ImpyMe)Cl]PF6, 1, and (R(Os),R(C))-[Os(η(6)-p-cym)(ImpyMe)Cl]PF6, 3. The two iodido complexes were evaluated in the National Cancer Institute 60-cell-line screen, by using the COMPARE algorithm. This showed that the two potent iodido complexes, 2 (NSC: D-758116/1) and 4 (NSC: D-758118/1), share surprisingly similar cancer cell selectivity patterns with the anti-microtubule drug, vinblastine sulfate. However, no direct effect on tubulin polymerization was found for 2 and 4, an observation that appears to indicate a novel mechanism of action. In addition, complexes 2 and 4 demonstrated potential as transfer-hydrogenation catalysts for imine reduction.
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