ArticlePflugers Archiv : European journal of physiology2014
Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis.
Article in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Prebiotics as modulators of colonic calcium and magnesium uptake.Acta physiologica (Oxford, England) · 2025Review
- Slow Sulfide Donor GYY4137 Increased the Sensitivity of Two Breast Cancer Cell Lines to Paclitaxel by Different Mechanisms.Biomolecules · 2024Article
- Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells.Frontiers in oncology · 2023Article
- Effect of CaS Nanostructures in the Proliferation of Human Breast Cancer and Benign Cells In Vitro.Applied sciences (Basel, Switzerland) · 2022Article
- Hydrogen Sulfide-Evoked Intracellular CaCancers · 2020Article
- Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors.Biomolecules · 2020Review
- Article
- Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies.Oxidative medicine and cellular longevity · 2019Review
- Endogenous HBMC cancer · 2018Article
- Differential regulation of nimodipine-sensitive and -insensitive CaJournal of biomedical science · 2018Article
- Sulfur-containing gaseous signal molecules, ion channels and cardiovascular diseases.British journal of pharmacology · 2018Review
- Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.Scientific reports · 2018Article
- Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through σ1R/IPCellular and molecular neurobiology · 2018Article
- Downregulation of NaChinese medical journal · 2017Article
- The Control of Calcium Metabolism in Zebrafish (Danio rerio).International journal of molecular sciences · 2016Review
- Essential role of Na+/Ca2+ exchanger 1 in smoking-induced growth and migration of esophageal squamous cell carcinoma.Oncotarget · 2016Article
- Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation.Experimental and therapeutic medicine · 2016Article
- Hydrogen sulfide promotes calcium uptake in larval zebrafish.American journal of physiology. Cell physiology · 2015Article
- Role of Na⁺/Ca²⁺ exchanger in Ca²⁺ homeostasis in rat suprachiasmatic nucleus neurons.Journal of neurophysiology · 2015Article
- Interaction of H2S with Calcium Permeable Channels and Transporters.Oxidative medicine and cellular longevity · 2015Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulfide (H2S) as a novel gasotransmitter regulates variety of processes, including calcium transport systems. Sodium calcium exchanger (NCX) is one of the key players in a regulation calcium homeostasis. Thus, the aims of our work were to determine effect of sulfide signaling on the NCX type 1 (NCX1) expression and function in HeLa cells, to investigate the relationship of β-adrenergic receptors with the NCX1 in the presence and/or absence of H2S, and to determine physiological importance of this potential communication. As a H2S donor, we used morpholin-4-ium-4-methoxyphenyl(morpholino) phosphinodithioate-GYY4137. We observed increased levels of the NCX1 mRNA, protein, and activity after 24 h of GYY4137 treatment. This increase was accompanied by elevated cAMP due to the GYY4137 treatment, which was completely abolished, when NCX1 was silenced. Increased cAMP levels would point to upregulation of β-adrenergic receptors. Indeed, GYY4137 increased expression of β1 and β3 (but not β2) adrenergic receptors. These receptors co-precipitated, co-localized with the NCX1, and induced apoptosis in the presence of H2S. Our results suggest that sulfide signaling plays a role in regulation of the NCX1, β1 and β3 adrenergic receptors, their co-localization, and stimulation of apoptosis, which might be of a potential importance in cancer treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.