ArticleDiabetologia2013
Immune cell-mediated inflammation and the early improvements in glucose metabolism after gastric banding surgery.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- The Interplay between Obesity and Inflammation.Life (Basel, Switzerland) · 2024Review
- T cells in obesity-associated inflammation: The devil is in the details.Immunological reviews · 2024Review
- Improved Insulin Secretion Response and Beta-cell Function Correlated with Increased Prolactin Levels After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients with Acanthosis Nigricans.Obesity surgery · 2023Article
- The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy.Frontiers in surgery · 2022Article
- Reduced Th1 response is associated with lower glycolytic activity in activated peripheral blood mononuclear cells after metabolic and bariatric surgery.Journal of endocrinological investigation · 2021Observational
- Determinants of type 2 diabetes remission after bariatric surgery in obese Japanese patients: a retrospective cohort study.Diabetology international · 2021Article
- Intravital imaging of islet CaNature communications · 2021Article
- Obesity-related cognitive impairment: The role of endothelial dysfunction.Neurobiology of disease · 2019Review
- Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?Seminars in immunopathology · 2019Review
- Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery.Oxidative medicine and cellular longevity · 2019Review
- Decreased Levels of Circulating Cancer-Associated Protein Biomarkers Following Bariatric Surgery.Obesity surgery · 2017Article
- Role of innate and adaptive immunity in obesity-associated metabolic disease.The Journal of clinical investigation · 2017Review
- Glucose Metabolism After Gastric Banding and Gastric Bypass in Individuals With Type 2 Diabetes: Weight Loss Effect.Diabetes care · 2017Article
- The impact of bariatric surgery on inflammation: quenching the fire of obesity?Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Article
- Role of T cells in malnutrition and obesity.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe contribution of immune cells to the inflammasome that characterises type 2 diabetes mellitus and obesity is under intense research scrutiny. We hypothesised that early changes in glucose metabolism following gastric banding surgery may relate to systemic inflammation, particularly cell-mediated immunity.
methodsObese participants (BMI 43.4 ± 4.9 kg/m(2), n = 15) with diabetes or impaired glucose tolerance (IGT) underwent laparoscopic adjustable gastric banding surgery. Measurements taken before, and at 2 and 12 weeks after surgery included: fasting glucose, glucose levels 2 h after a 75 g oral load, glucose incremental AUC, oral glucose insulin sensitivity index (OGIS), circulating immune cell numbers and activation, and adipokine levels. Subcutaneous and visceral adipose tissue were collected at surgery, and macrophage number and activation measured.
resultsThere were significant reductions in fasting and 2 h glucose, as well as improved OGIS at 2 and 12 weeks. At 12 weeks, 80% of the diabetic participants reverted to normal glucose tolerance or IGT, and all IGT participants had normalised glucose tolerance. The 12 week fall in fasting glucose was significantly related to baseline lymphocyte and T lymphocyte numbers, and to granulocyte activation, but also to the magnitude of the 12 week reduction in lymphocyte and T lymphocyte numbers and TNF-α levels. In a model that explained 75% of the variance in the change in fasting glucose, the 12 week change in T lymphocytes was independently associated with the 12 week fall in fasting glucose. CONCLUSIONS/
interpretationRapid improvements in glucose metabolism after gastric banding surgery are related to reductions in circulating pro-inflammatory immune cells, specifically T lymphocytes. The contribution of immune cell-mediated inflammation to glucose homeostasis in type 2 diabetes and its improvement after bariatric surgery require further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.