ArticleJapanese journal of ophthalmology2013
Three-dimensional imaging of the inner limiting membrane folding on the vitreomacular interface in diabetic macular edema.
Article in Japanese journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Comparison of microinsicion vitrectomy and conventional 20-gauge vitrectomy for severe proliferative diabetic retinopathy.Japanese journal of ophthalmology · 2015Trial
- Pars plana vitrectomy for tractional diabetic macular edema with or without internal limiting membrane peeling.Medical hypothesis, discovery & innovation ophthalmology journal · 2022Article
- Vitreous and intraretinal macular changes in diabetic macular edema with and without tractional components.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Review
- Retinal findings in a patient of French ancestry with CABP4-related retinal disease.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- Management of diabetic macular edema in Japan: a review and expert opinion.Japanese journal of ophthalmology · 2018Review
- The Vitreomacular Interface in Diabetic Retinopathy.Journal of ophthalmology · 2015Review
- Vision-related quality of life and visual function following intravitreal bevacizumab injection for persistent diabetic macular edema after vitrectomy.Japanese journal of ophthalmology · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the findings of fine folds on the retina obtained by spectral-domain optical coherence tomography (OCT).
methodsA retrospective non-comparative case series; 26 eyes of diabetic macular edema (DME) patients who underwent vitrectomy were observed using three-dimensional (3D) images of OCT preoperatively and postoperatively. The specimens were investigated immunohistochemically.
resultsUsing only tomography, non-tractional vitreoretinal interfaces were observed in 15 eyes and tractional vitreoretinal interfaces in the other 11 eyes. Using 3D imaging, we observed fine folds in 11 eyes among 15 cases showing non-tractional interfaces. Based on these findings, the state of the vitreoretinal interface was classified into 3 patterns. Group 1, both tomography and 3D imaging showed smooth retinal surfaces. Group 2, tomography showed a smooth retinal surface, but 3D imaging showed fine folds on the retina. Group 3, both tomography and 3D imaging showed a tractional vitreoretinal interface with an obvious epiretinal membrane and/or taut posterior vitreous cortex. The fine folds in group 2 disappeared and macular edema improved after inner limiting membrane (ILM) peeling, and the CRT of groups 2 and 3 reduced significantly. The fine folds were confirmed to involve the ILM because type IV collagen expression was detected in the surgically obtained specimens.
conclusionWe observed tangential fine folds of the ILM. These were detected by using only 3D imaging, and might be useful for investigating the optimal indication of vitrectomy for DME.
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