ArticleArchives of osteoporosis2013
Longitudinal relationships between whole body and central adiposity on weight-bearing bone geometry, density, and bone strength: a pQCT study in young girls.
Article in Archives of osteoporosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
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- Forearm Fractures in Overweight-Obese Children and Adolescents: A Matter of Bone Density, Bone Geometry or Body Composition?Calcified tissue international · 2022Review
- Childhood adiposity, adult adiposity, and bone health.Pediatric investigation · 2021Article
- Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day.Animals : an open access journal from MDPI · 2021Article
- Associations between body mass index, body composition and bone density in young adults: findings from a southern Brazilian cohort.BMC musculoskeletal disorders · 2019Article
- The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019Review
- The role of PPARγ in childhood obesity-induced fractures.Genes & nutrition · 2019Review
- Fat and bone in children - where are we now?Annals of pediatric endocrinology & metabolism · 2018Article
- The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children.Calcified tissue international · 2017Review
- Longitudinal bone, muscle and adipose tissue changes in physically active subjects - sex differences during adolescence and maturity.Journal of musculoskeletal & neuronal interactions · 2016Article
- Bone-adiposity cross-talk: implications for pediatric obesity. A narrative review of literature.Journal of bone and mineral metabolism · 2015Review
- Article
- Tibia and radius bone geometry and volumetric density in obese compared to non-obese adolescents.Bone · 2015Article
- Overweight and obesity in hip and knee arthroplasty: Evaluation of 6078 cases.World journal of orthopedics · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledLongitudinal relationships between adiposity (total body and central) and bone development were assessed in young girls. Total body and android fat masses were positively associated with bone strength and density parameters of the femur and tibia. These results suggest adiposity may have site-specific stimulating effects on the developing bone.
introductionChildhood obesity may impair bone development, but the relationships between adiposity and bone remain unclear. Failure to account for fat pattern may explain the conflicting results. PURPOSE: Longitudinal associations of total body fat mass (TBFM) and android fat mass (AFM) with 2-year changes in weight-bearing bone parameters were examined in 260 girls aged 8-13 years at baseline. Peripheral quantitative computed tomography was used to measure bone strength index (BSI, square milligrams per quartic millimeter), strength-strain index (SSI, cubic millimeters), and volumetric bone mineral density (vBMD, milligrams per cubic centimeter) at distal metaphyseal and diaphyseal regions of the femur and tibia. TBFM and AFM were assessed by dual-energy x-ray absorptiometry.
resultsBaseline TBFM and AFM were positively associated with the change in femur BSI (r = 0.20, r = 0.17, respectively) and femur trabecular vBMD (r = 0.19, r = 0.19, respectively). Similarly, positive associations were found between TBFM and change in tibia BSI and SSI (r = 0.16, r = 0.15, respectively), and femur total and trabecular vBMD (r = 0.12, r = 0.14, respectively). Analysis of covariance showed that girls in the middle thirds of AFM had significantly lower femur trabecular vBMD and significantly higher tibia cortical vBMD than girls in the highest thirds of AFM. All results were significant at p < 0.05.
conclusionsWhereas baseline levels of TBFM and AFM are positive predictors of bone strength and density at the femur and tibia, higher levels of AFM above a certain level may impair cortical vBMD growth at weight-bearing sites. Future studies in obese children will be needed to test this possibility.
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