ArticleExperimental cell research2014
Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway.
Article in Experimental cell research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Application of electrospun piezoelectric nanofibers in wound healing.Burns & trauma · 2026Review
- Cellular and molecular roles of reactive oxygen species in wound healing.Communications biology · 2024Review
- [Research progress of metal micro-battery dressings in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment.Inflammation and regeneration · 2022Review
- Co-implantation of magnesium and zinc ions into titanium regulates the behaviors of human gingival fibroblasts.Bioactive materials · 2021Article
- Evaluation of the In Vitro Oral Wound Healing Effects of Pomegranate (Biomolecules · 2020Article
- Antibiotics Affect ROS Production and Fibroblast Migration in anFrontiers in cellular and infection microbiology · 2020Article
- A novel microcurrent dressing for wound healing in a rat skin defect model.Military Medical Research · 2019Article
- Zinc in Wound Healing Modulation.Nutrients · 2017Review
- Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process.International wound journal · 2017Article
- Early bioelectric activities mediate redox-modulated regeneration.Development (Cambridge, England) · 2016Article
- GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.Molecular medicine reports · 2016Article
- Monophasic Pulsed Microcurrent of 1-8 Hz Increases the Number of Human Dermal Fibroblasts.Progress in rehabilitation medicine · 2016Article
- Effects and mechanisms of a microcurrent dressing on skin wound healing: a review.Military Medical Research · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Electrical signals have been implied in many biological mechanisms, including wound healing, which has been associated with transient electrical currents not present in intact skin. One method to generate electrical signals similar to those naturally occurring in wounds is by supplementation of galvanic particles dispersed in a cream or gel. We constructed a three-layered model of skin consisting of human dermal fibroblasts in hydrogel (mimic of dermis), a hydrogel barrier layer (mimic of epidermis) and galvanic microparticles in hydrogel (mimic of a cream containing galvanic particles applied to skin). Using this model, we investigated the effects of the properties and amounts of Cu/Zn galvanic particles on adult human dermal fibroblasts in terms of the speed of wound closing and gene expression. The collected data suggest that the effects on wound closing are due to the ROS-mediated enhancement of fibroblast migration, which is in turn mediated by the BMP/SMAD signaling pathway. These results imply that topical low-grade electric currents via microparticles could enhance wound healing.
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