Evidence map›Paper›PMID 24113565›Full record

ReviewEpilepsy & behavior : E&B2014

Complex metabolically demanding sensory processing in the olfactory system: implications for epilepsy.

Diego Restrepo, Jennifer L Hellier, Ernesto Salcedo

Abstract readReview
In one paragraph

Review in Epilepsy & behavior : E&B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Seizure treatment with olfactory training: a preliminary trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Domoic acid epileptic disease.Marine drugs · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Diego RestrepoDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: diego.restrepo@ucdenver.edu.
Jennifer L HellierRocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ernesto SalcedoDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
University of Colorado Anschutz Medical Campus · USRocky Mountain MS Center · US

Funding

PERIPHERAL MECHANISMS OF OLFACTORY RECEPTIONR01DC000566 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI RESTREPO, DIEGO · 1989 to 2022
$9.9M
Multiple Mechanisms of Nasal ChemoreceptionR01DC006070 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI FINGER, THOMAS E, RESTREPO, DIEGO · 2003 to 2012
$5.0M
NIDCD NIH HHS DC00566NIDCD NIH HHS DC006070NIDCD NIH HHS R01 DC000566NIDCD NIH HHS R01 DC006070
6 · The paper itself

Abstract

Although the olfactory system is not generally associated with seizures, sharp application of odor eliciting activity in a large number of olfactory sensory neurons (OSNs) has been shown to elicit seizures. This is most likely due to increased ictal activity in the anterior piriform cortex-an area of the olfactory system that has limited GABAergic interneuron inhibition of pyramidal output cell activity. Such hyperexcitability in a well-characterized and highly accessible system makes olfaction a potentially powerful model system to examine epileptogenesis.

Indexed as

AnimalsEpilepsyGABAergic NeuronsOlfactory BulbOlfactory PerceptionPiriform CortexEpilepsyOlfactionOlfactory bulbPiriform

Identifiers

PMID24113565
PMCPMC3979506
OpenAlexW1968186522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.