Questions on the role of the EPR effect in tumor targeting.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Liposomal Nanoparticulate Drug Delivery Systems: Strategies to Destabilize Biological Membranes at the Target Tissue.International journal of nanomedicine · 2026
   Review
2. Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives.Oncology research · 2026
   Review
3. Inhalable Nanoparticle-based Dry Powder Formulations for Respiratory Diseases: Challenges and Strategies for Translational Research.AAPS PharmSciTech · 2023
   Review
4. Principles of Nanoparticle Delivery to Solid Tumors.BME frontiers · 2023
   Review
5. Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors.Journal of personalized medicine · 2022
   Review
6. Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma.Cancers · 2022
   Article
7. CRPC Membrane-Camouflaged, Biomimetic Nanosystem for Overcoming Castration-Resistant Prostate Cancer by Cellular Vehicle-Aided Tumor Targeting.International journal of molecular sciences · 2022
   Article
8. EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect.Journal of personalized medicine · 2021
   Article
9. Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors.Frontiers in oncology · 2020
   Review
10. Development of β-elemene and Cisplatin Co-Loaded Liposomes for Effective Lung Cancer Therapy and Evaluation in Patient-Derived Tumor Xenografts.Pharmaceutical research · 2019
    Article
11. DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement.Molecular pharmaceutics · 2018
    Article
12. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs.Clinical and translational medicine · 2018
    Article
13. A multi-functional nanoplatform for efficacy tumor theranostic applications.Asian journal of pharmaceutical sciences · 2017
    Article
14. Vascular targeting of nanoparticles for molecular imaging of diseased endothelium.Advanced drug delivery reviews · 2017
    Review
15. Crossing the barrier: treatment of brain tumors using nanochain particles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016
    Review
16. A New Concept of Enhancing Immuno-Chemotherapeutic Effects Against B16F10 TumorTheranostics · 2016
    Article
17. Improved anticancer delivery of paclitaxel by albumin surface modification of PLGA nanoparticles.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015
    Article
18. Synthesis and characterisation of ultrasound imageable heat-sensitive liposomes for HIFU therapy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2015
    Article
19. Thermosensitive liposomal drug delivery systems: state of the art review.International journal of nanomedicine · 2014
    Review

Corrections and comments

• Comment on
  Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery.2013

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as