ArticleThe American journal of pathology2013
Hyperglycemia impairs atherosclerosis regression in mice.
Article in The American journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Macrophage immunometabolism in diabetes-associated atherosclerosis.Immunometabolism (Cobham, Surrey) · 2023Review
- The RAGE/DIAPH1 Signaling Axis & Implications for the Pathogenesis of Diabetic Complications.International journal of molecular sciences · 2022Review
- High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.iScience · 2021Article
- Cardiovascular disease in diabetes, beyond glucose.Cell metabolism · 2021Review
- Diabetes and Cardiovascular Complications: The Epidemics Continue.Current cardiology reports · 2021Review
- Inflammation Meets Metabolism: Roles for the Receptor for Advanced Glycation End Products Axis in Cardiovascular Disease.Immunometabolism · 2021Article
- RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.JCI insight · 2020Article
- Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice.JCI insight · 2020Article
- Atherosclerosis: Making a U Turn.Annual review of medicine · 2020Review
- Macrophages in Atherosclerosis Regression.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation.Circulation · 2019Article
- Large-scale gene analysis of rabbit atherosclerosis to discover new biomarkers for coronary artery disease.Open biology · 2019Article
- Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice.Diabetes · 2018Article
- An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury.American journal of physiology. Renal physiology · 2017Article
- Article
- Antioxidant and anti-atherosclerotic potential of Banana (Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Diabetic patients are known to be more susceptible to atherosclerosis and its associated cardiovascular complications. However, the effects of hyperglycemia on atherosclerosis regression remain unclear. We hypothesized that hyperglycemia impairs atherosclerosis regression by modulating the biological function of lesional macrophages. HypoE (Apoe(h/h)Mx1-Cre) mice express low levels of apolipoprotein E (apoE) and develop atherosclerosis when fed a high-fat diet. Atherosclerosis regression occurs in these mice upon plasma lipid lowering induced by a change in diet and the restoration of apoE expression. We examined the morphological characteristics of regressed lesions and assessed the biological function of lesional macrophages isolated with laser-capture microdissection in euglycemic and hyperglycemic HypoE mice. Hyperglycemia induced by streptozotocin treatment impaired lesion size reduction (36% versus 14%) and lipid loss (38% versus 26%) after the reversal of hyperlipidemia. However, decreases in lesional macrophage content and remodeling in both groups of mice were similar. Gene expression analysis revealed that hyperglycemia impaired cholesterol transport by modulating ATP-binding cassette A1, ATP-binding cassette G1, scavenger receptor class B family member (CD36), scavenger receptor class B1, and wound healing pathways in lesional macrophages during atherosclerosis regression. Hyperglycemia impairs both reduction in size and loss of lipids from atherosclerotic lesions upon plasma lipid lowering without significantly affecting the remodeling of the vascular wall.
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