Evidence map›Paper›PMID 24113214›Full record

ReviewBiotechnology advances

Nanoparticles containing insoluble drug for cancer therapy.

Shutao Guo, Leaf Huang

Abstract readReview
In one paragraph

Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shutao GuoDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Leaf HuangDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: leafh@unc.edu.

Funding

Translational Nanosystems for Improved Lung Cancer Treatment with Small MoleculesU54CA151652 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAROON, ZISHAN A, TEPPER, JOEL E · 2010 to 2014
$12.1M
Nanoscale Metal-organic Frameworks for Imaging and Therapy of Pancreatic CancerU01CA151455 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, WENBIN, YEH, JEN JEN · 2010 to 2014
$2.1M
LPD Nanoparticles in Anti-Cancer TherapyR01CA129835 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUANG, LEAF · 2008 to 2012
$1.5M
Interaction of cationic lipids with dendritic cellsR01CA129421 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUANG, LEAF · 2008 to 2012
$1.5M
Novel nanoparticles for siRNA deliveryR01CA149363 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUANG, LEAF · 2010 to 2014
$1.3M
NCI NIH HHS CA129421NCI NIH HHS CA129835NCI NIH HHS CA149363NCI NIH HHS CA151455NCI NIH HHS CA151652NCI NIH HHS R01 CA129421NCI NIH HHS R01 CA129835NCI NIH HHS R01 CA149363NCI NIH HHS U01 CA151455NCI NIH HHS U54 CA151652
6 · The paper itself

Abstract

Nanoparticle drug formulations have been extensively researched and developed in the field of drug delivery as a means to efficiently deliver insoluble drugs to tumor cells. By mechanisms of the enhanced permeability and retention effect, nanoparticle drug formulations are capable of greatly enhancing the safety, pharmacokinetic profiles and bioavailability of the administered treatment. Here, the progress of various nanoparticle formulations in both research and clinical applications is detailed with a focus on the development of drug/gene delivery systems. Specifically, the unique advantages and disadvantages of polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanocrystals and lipid-coated nanoparticles for targeted drug delivery will be investigated in detail.

Indexed as

Drug Delivery SystemsAntineoplastic AgentsGoldHumansLipidsLiposomesMetal NanoparticlesNanomedicineNanoparticlesPermeabilityPolymersRNA, Small InterferingAntineoplastic AgentsGoldLipidsLiposomesPolymersRNA, Small InterferingCalcium phosphateDrug deliveryGold nanoparticleLipidLiposomeNanocrystalsNanoparticlePolymersiRNA

Identifiers

PMID24113214
PMCPMC3980181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.