ArticleAquatic toxicology (Amsterdam, Netherlands)2013
Transcription patterns of genes encoding four metallothionein homologs in Daphnia pulex exposed to copper and cadmium are time- and homolog-dependent.
Article in Aquatic toxicology (Amsterdam, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular bioindicators for assessing environmental impacts of emerging contaminants.Fundamental research · 2026Review
- Discovery and Evaluation of Cadmium-Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium-Induced Mutations.Molecular ecology · 2026Article
- Myriapod Metallothioneins Conserve the Ancestral Architecture of Arthropods While Displaying Lineage-Specific Adaptations in Metal Binding.Genome biology and evolution · 2026Article
- History of exposure to copper influences transgenerational gene expression responses inEpigenetics · 2024Article
- Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective.BMC genomics · 2024Article
- Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells.Cells · 2023Article
- Daphnia as a model organism to probe biological responses to nanomaterials-from individual to population effects via adverse outcome pathways.Frontiers in toxicology · 2023Review
- Influence of water hardness on zinc toxicity in Daphnia magna.Journal of applied toxicology : JAT · 2022Article
- Maternal Responses and Adaptive Changes to Environmental Stress via Chronic Nanomaterial Exposure: Differences in Inter and Transgenerational Interclonal Broods ofInternational journal of molecular sciences · 2020Article
- Metallothionein in Hermetia illucens (Linnaeus, 1758) larvae (Diptera: Stratiomyidae), a potential biomarker for organic waste system.Environmental science and pollution research international · 2018Article
- Effects of fluctuating temperature and food availability on reproduction and lifespan.Experimental gerontology · 2016Article
- The effect of a low iron diet and early life methylmercury exposure in Daphnia pulex.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
- Effects of early life exposure to methylmercury in Daphnia pulex on standard and reduced food ration.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals.Biomolecules · 2014Review
- Genome-wide transcription profiles reveal genotype-dependent responses of biological pathways and gene-families in Daphnia exposed to single and mixed stressors.Environmental science & technology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Metallothioneins are proteins that play an essential role in metal homeostasis and detoxification in nearly all organisms studied to date. Yet discrepancies between outcomes of chronic and acute exposure experiments hamper the understanding of the regulatory mechanisms of their isoforms following metal exposure. Here, we investigated transcriptional differences among four identified homologs (mt1-mt4) in Daphnia pulex exposed across time to copper and cadmium relative to a control. Transcriptional upregulation of mt1 and mt3 was detected on day four following exposure to cadmium, whereas that of mt2 and mt4 was detected on day two and day eight following exposure to copper. These results confirm temporal and metal-specific differences in the transcriptional induction of genes encoding metallothionein homologs upon metal exposure which should be considered in ecotoxicological monitoring programs of metal-contaminated water bodies. Indeed, the mRNA expression patterns observed here illustrate the complex regulatory system associated with metallothioneins, as these patterns are not only dependent on the metal, but also on exposure time and the homolog studied. Further phylogenetic analysis and analysis of regulatory elements in upstream promoter regions revealed a high degree of similarity between metallothionein genes of Daphnia pulex and Daphnia magna, a species belonging to the same genus. These findings, combined with a limited amount of available expression data for D. magna metallothionein genes, tentatively suggest a potential generalization of the metallothionein response system between these Daphnia species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.