ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2013
[Progressive patterns of gifitinib treating advanced non-small cell lung cancer after obtained resistance].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveClinical observation was conducted on the resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) gefitinib (Iressa) therapy for advanced non-small cell lung cancer (NSCLC) patients.
methodsNinety-three NSCLC patients in our hospital, showing effective or stable condition after 6-month previous gefitinib therapy, were included in this investigation. Among the patients, 94.6% of them were suffering from adenocarcinoma. The percentage of female is 79.6%; the percentage of non-smoking is 80.6%. During the therapy period, follow-up was preformed every 2 months.
resultsAmong the 93 patients, median therapy time was 16 months (range: 8 to 70 months), and 21.5% (20/93) of them had received therapy for more than 2 years, while 8.6% (8/93) had received that for more than 3 years. The progression included 80% (72/90) for intrapleural progression, 38.9% (35/90) for primary tumor plus recurrence after sugary especially, 51.1% (46/90) for intrapulmonary metastasis, 25.6% (23/90) for pleural metastasis, 30% (30/90) for intracranial progression and 15.6% (14/90) for intraperitoneal progression.
conclusionResistance to EGFR-TKI shows diversification in clinical observation, therefore, close clinical follow-up is necessary for early attention and timely treatment.
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