ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2014
Association between maternal iron supplementation during pregnancy and risk of celiac disease in children.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pooled it
- The Role of Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery.The review of diabetic studies : RDSPooled it
- Longitudinal micronutrient exposure reveals country-specific associations with risk of celiac disease in genetically susceptible children: the prospective TEDDY cohort.The American journal of clinical nutrition · 2026Article
- Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.Medicina (Kaunas, Lithuania) · 2026Review
- Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study.BMJ open gastroenterology · 2024Article
- Coeliac disease: what can we learn from prospective studies about disease risk?The Lancet. Child & adolescent health · 2024Review
- Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study.PLoS medicine · 2020Observational
- Potential risk factors for celiac disease in childhood: a case-control epidemiological survey.Clinical and experimental gastroenterology · 2019Article
- Clinical Relevance of Gastrointestinal Microbiota During Pregnancy: A Primer for Nurses.Biological research for nursing · 2018Article
- Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies.Frontiers in pediatrics · 2018Review
- Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study.The British journal of nutrition · 2017Article
- Immunopathogenesis and therapeutic approaches in pediatric celiac disease.Expert review of clinical immunology · 2016Review
- Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board.The American journal of gastroenterology · 2016Article
- Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.Digestive diseases and sciences · 2015Article
- An unprecedented dual antagonist and agonist of human Transglutaminase 2.Bioorganic & medicinal chemistry letters · 2015Article
- The coeliac stomach: gastritis in patients with coeliac disease.Alimentary pharmacology & therapeutics · 2015Article
- Perinatal risk factors for development of celiac disease in children, based on the prospective Norwegian Mother and Child Cohort Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- The unfolding story of celiac disease risk factors.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014Article
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5 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsThe aim of our study was to determine whether the use of iron supplements during pregnancy affects the risk for celiac disease in children.
methodsWe assessed data from the prospective Norwegian Mother and Child cohort study, in which individuals with celiac disease were identified by answers on questionnaires and linkage to the Norwegian Patient Register. Complete data were available for 78,846 children (mean age 5.9 years, range 2-12 years); 314 children were identified with celiac disease. Questionnaires were given to pregnant women to collect information on use of iron-containing supplements, diet, anemia, and levels of hemoglobin.
resultsCeliac disease was diagnosed in 4.65 of 1000 children whose mothers took iron supplements while they were pregnant, compared with 3.15 of 1000 children whose mothers did not. After adjusting for children's age, sex, and age of gluten introduction, and the presence of celiac disease in mothers, iron supplementation during pregnancy remained significantly associated with celiac disease in children (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.05-1.68; P = .019). However, celiac disease was not associated with the mothers' intake of iron from foods (adjusted OR, 1.00; 95% CI, 0.97-1.03). Anemia before or during the early stages of pregnancy was not significantly associated with the risk of celiac disease in children (adjusted OR, 1.24; 95% CI, 0.84-2.00; P = .24). The use of iron supplements during pregnancy remained significantly associated with celiac disease in children after adjusting for children who were given iron supplements before 18 months of age, which itself was associated with celiac disease.
conclusionsIn a prospective Norwegian Mother and Child cohort study, we found an increased risk of celiac disease in children whose mothers used iron supplements during pregnancy; this association does not appear to arise from maternal anemia.
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