Evidence map›Paper›PMID 24112861›Full record

ArticleThe Journal of pediatrics2014

Vitamin D, race, and risk for anemia in children.

Meredith A Atkinson, Michal L Melamed, Juhi Kumar, Cindy N Roy, Edgar R Miller, Susan L Furth, Jeffrey J Fadrowski

Abstract readComparative Study
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 88 citations in OpenAlex.

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  18. The effect of iron dextran on vitamin DNutrition & metabolism · 2022
    Article
  19. Review
  20. The Association between Standardized Serum 25-HydroxyvitaminInternational journal of clinical practice · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Meredith A AtkinsonDivision of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: matkins3@jhmi.edu.
Michal L MelamedDepartments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY.
Juhi KumarDivision of Pediatric Nephrology, Weill Cornell Medical College, New York, NY.
Cindy N RoyDivisions of Hematology and Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD.
Edgar R MillerWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University School of Medicine, Baltimore, MD.
Susan L FurthThe Children's Hospital of Philadelphia, Philadelphia, PA.
Jeffrey J FadrowskiDivision of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins Medicine · USAlbert Einstein College of Medicine · USChildren's Hospital of Philadelphia · USCornell University · USJohns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2013 to 2017
$9.7M
Patient Oriented Research in Pediatric Kidney DiseaseK24DK078737 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FURTH, SUSAN L. · 2007 to 2016
$1.6M
Hepcidin and Anemia in Children: Mechanisms and ModifiersK23DK084116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ATKINSON, MEREDITH ANN · 2011 to 2015
$855k
Racial Disparities in Chronic Kidney Disease and Vitamin D: Are they related?K23DK078774 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MELAMED, MICHAL L · 2007 to 2011
$769k
Alkali Therapy in Chronic Kidney DiseaseR01DK087783 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HOSTETTER, THOMAS HEARD · 2010 to 2012
$750k
NCATS NIH HHS UL1 TR001079NIDDK NIH HHS K23 DK078774NIDDK NIH HHS K23-DK-078774NIDDK NIH HHS K23 DK084116NIDDK NIH HHS K23-DK-084116NIDDK NIH HHS K24 DK078737NIDDK NIH HHS P30 DK079637NIDDK NIH HHS R01 DK087783NIDDK NIH HHS R01DK087783
6 · The paper itself

Abstract

objectiveTo examine the association between 25-hydroxyvitamin D [25(OH)D] deficiency and anemia in a cohort of otherwise-healthy children and to determine whether race modifies the association between 25(OH)D status and hemoglobin (Hgb). STUDY

designCross-sectional study of 10,410 children and adolescents ages 1-21 years from the 2001-2006 National Health and Nutrition Examination Survey. Anemia was defined as Hgb less than the 5th percentile for age and sex based on National Health and Nutrition Examination Survey III (1988-1994) data.

resultsLower 25(OH)D levels were associated with increased risk for anemia; <30 ng/mL, adjusted OR 1.93, 95% CI 1.21-3.08, P = .006, and <20 ng/mL, OR 1.47, 95% CI 1.14-1.89, P = .004. In linear regression, small but significant increases in Hgb were noted in the upper quartiles of 25(OH)D compared with the lowest quartile (<20 ng/mL) in the full cohort. Results of race-stratified linear regression by 25(OH)D quartile in white children were similar to those observed in the full cohort, but in black children, an increase in Hgb in the upper 25(OH)D quartiles was only apparent compared with the lowest black race-specific quartile (<12 ng/mL).

conclusion25(OH)D deficiency is associated with increased risk of anemia in healthy US children, but the 25(OH)D threshold levels for lower Hgb are lower in black children in comparison with white children.

Indexed as

Nutrition SurveysRacial GroupsAdolescentAge DistributionAnemiaChildChild, PreschoolCross-Sectional StudiesFemaleHemoglobinsHumansIncidenceInfantMaleRetrospective StudiesRisk Factors25-hydroxyvitamin DHemoglobinsVitamin D25-Hydroxyvitamin D25(OH)DBMIBody mass indexCDCCenters for Disease Control and PreventionChronic kidney diseaseCKDC-reactive proteinCRPErythropoiesis-stimulating agentESAGFRGlomerular filtration rateHemoglobinHgbNational Health and Nutrition Examination SurveyNHANESTIBCTotal iron-binding capacity

Identifiers

PMID24112861
PMCPMC3872204
OpenAlexW1978616014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.