ArticleMolecular microbiology2013
Comparative study of SoxR activation by redox-active compounds.
Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Mutations in the superoxide-responsive regulator SoxR confer fluoroquinolone resistance inCurrent research in microbial sciences · 2026Article
- The Role of the [2Fe-2S] Cluster of Escherichia coli IscR in Responding to Redox-Cycling Agents.Molecular microbiology · 2025Article
- The Iron-Sulfur Cluster of Bacterioferritin-Associated Ferredoxin (Bfd): a "Biological Fuse" that Prevents Oxidative Damage to Cells?Angewandte Chemie (International ed. in English) · 2025Article
- Functional Characterization of RseC in the SoxR Reducing System and Its Role in Oxidative Stress Response inJournal of microbiology and biotechnology · 2024Article
- Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor.Microbial cell factories · 2024Article
- A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolites.Current opinion in chemical biology · 2023Review
- LexR Positively Regulates the LexABC Efflux Pump Involved in Self-Resistance to the Antimicrobial Di-Microbiology spectrum · 2023Article
- A Plasmid-Based Fluorescence Reporter System for Monitoring Oxidative Damage inSensors (Basel, Switzerland) · 2022Article
- Phenazines and toxoflavin act as interspecies modulators of resilience to diverse antibiotics.Molecular microbiology · 2022Article
- Synthetic biology and bioelectrochemical tools for electrogenetic system engineering.Science advances · 2022Article
- Characterization of components of a reducing system for SoxR in the cytoplasmic membrane of Escherichia coli.Journal of microbiology (Seoul, Korea) · 2022Article
- From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance.Nature reviews. Microbiology · 2022Review
- Interaction of Periplasmic Fab Production and Intracellular Redox Balance inACS synthetic biology · 2022Article
- Redox-sensitive transcriptional regulator SoxR directly controls antibiotic production, development and thiol-oxidative stress response in Streptomyces avermitilis.Microbial biotechnology · 2022Article
- Oxidative Stress Response inPathogens (Basel, Switzerland) · 2021Review
- Resistance-Nodulation-Division Efflux Pump, LexABC, Contributes to Self-Resistance of the Phenazine Di-Frontiers in microbiology · 2021Article
- Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis.PLoS genetics · 2020Article
- Copper primes adaptation of uropathogenic Escherichia coli to superoxide stress by activating superoxide dismutases.PLoS pathogens · 2020Article
- The Potential for Redox-Active Metabolites To Enhance or Unlock Anaerobic Survival Metabolisms in Aerobes.Journal of bacteriology · 2020Review
- Sublethal Paraquat Confers Multidrug Tolerance inFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
SoxR from Escherichia coli and related enterobacteria is activated by a broad range of redox-active compounds through oxidation or nitrosylation of its [2Fe-2S] cluster. Activated SoxR then induces SoxS, which subsequently activates more than 100 genes in response. In contrast, non-enteric SoxRs directly activate their target genes in response to redox-active compounds that include endogenously produced metabolites. We compared the responsiveness of SoxRs from Streptomyces coelicolor (ScSoxR), Pseudomonas aeruginosa (PaSoxR) and E. coli (EcSoxR), all expressed in S. coelicolor, towards natural or synthetic redox-active compounds. EcSoxR responded to all compounds examined, whereas ScSoxR was insensitive to oxidants such as paraquat (Eh -440 mV) and menadione sodium bisulphite (Eh -45 mV) and to NO generators. PaSoxR was insensitive only to some NO generators. Whole-cell EPR analysis of SoxRs expressed in E. coli revealed that the [2Fe-2S](1+) of ScSoxR was not oxidizable by paraquat, differing from EcSoxR and PaSoxR. The mid-point redox potential of purified ScSoxR was determined to be -185 ± 10 mV, higher by approximately 100 mV than those of EcSoxR and PaSoxR, supporting its limited response to paraquat. The overall sensitivity profile indicates that both redox potential and kinetic reactivity determine the differential responses of SoxRs towards various oxidants.
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