Trial reportTropical medicine & international health : TM & IH2013
Incidence of and risk factors for neonatal jaundice among newborns in southern Nepal.
Trial report in Tropical medicine & international health : TM & IH, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- The Effect of High and Low Ambient Temperature on Infant Health: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Comparison of effect of massage or chicory bath on bilirubin levels in term newborns undergoing phototherapy: a randomized clinical trial.BMC pediatrics · 2025Trial
- Sex differences in morbidity and care-seeking during the neonatal period in rural southern Nepal.Journal of health, population, and nutrition · 2015Trial
- Treatment outcome of neonatal jaundice and its predictors among neonates admitted at NICU in Bahir Dar city public hospitals: a multi-center retrospective follow-up study.BMC pediatrics · 2026Article
- Factors influencing jaundice follow-up rates in a multi-ethnic Asian population: a cross-sectional study.BMJ paediatrics open · 2026Article
- Incidence and risk factors for neonatal jaundice in a teaching hospital in Northern Ghana.BMC pediatrics · 2025Article
- Phototherapy Induced Hypocalcemia in Term and Preterm Neonates with Hyperbilirubinemia: A Cross-Sectional Study.JNMA; journal of the Nepal Medical Association · 2025Article
- Determinants of neonatal jaundice among neonates admitted to neonatal intensive care unit in hospitals of Gurage zone, Southern Ethiopia.BMC pediatrics · 2025Article
- Article
- Determinants of jaundice severity in neonates admitted at a Teaching Hospital in Ghana.PloS one · 2025Article
- Factors associated with neonatal jaundice among neonates admitted at referral hospitals in northeast Ethiopia: a facility-based unmatched case-control study.BMC pregnancy and childbirth · 2024Review
- Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study.Heliyon · 2024Article
- Magnitude and its associated factors of neonatal jaundice among neonates admitted to the neonatal intensive care unit of Dessie Town public hospitals, Amhara region, Ethiopia, 2020: a multicenter cross-sectional study.Frontiers in pediatrics · 2024Article
- Comparison of Phototherapy Effect with and without Phenobarbital on the Newborns with Hyperbilirubinemia.Iranian journal of child neurology · 2024Article
- Osmotic demyelination syndrome caused by rapid correction of hyperammonemia and continuous hyperbilirubinemia: a case report and review of the literature.Encephalitis (Seoul, Korea) · 2023Article
- Feasibility and acceptability of home-based neonatal hyperbilirubinemia screening by community health workers using transcutaneous bilimeters in Bangladesh.BMC pediatrics · 2023Article
- Maternal blood parameters and risk of neonatal pathological jaundice: a retrospective study.Scientific reports · 2023Article
- Newborn care in Northern India: A study of regional and seasonal peculiarities for desired professionalism and definitive practices.Journal of family medicine and primary care · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo quantify the incidence of and risk factors for neonatal jaundice among infants referred for care from a rural, low-resource, population-based cohort in southern Nepal.
methodsStudy participants were 18,985 newborn infants born in Sarlahi District in southern Nepal from May 2003 through January 2006 who participated in a cluster-randomised, placebo-controlled, community-based trial to evaluate the effect of newborn chlorhexidine cleansing on neonatal mortality and morbidity. Jaundice was assessed based on visual assessment of the infant by a study worker and referral for care. Adjusted relative risks (RR) were estimated to identify risk factors for referral for neonatal jaundice using Poisson regression.
resultsThe incidence of referral for neonatal jaundice was 29.3 per 1000 live births (95% confidence interval: 26.9, 31.7). Male sex, high birth weight, breastfeeding patterns, warm air temperature, primiparity, skilled birth attendance, place of delivery, prolonged labour, oil massage, paternal education and ethnicity were significant risk factors (P-values < 0.01). After multivariable adjustment, sex, birth weight, difficulty feeding, prolonged labour, primiparity, oil massage, ambient air temperature and ethnicity remained important factors. Among infants with difficulty feeding, exclusive breastfeeding was a risk factor for neonatal jaundice, whereas exclusive breastfeeding was protective among infants with no report of difficulty feeding.
conclusionsSeveral known risk factors for neonatal jaundice in a low-resource setting were confirmed in this study. Unique observed associations of jaundice with ambient air temperature and oil massage may be explained by the opportunity for phototherapy based on the cultural practices of this study population. Future research should investigate the role of an infant's difficulty in feeding as a potential modifier in the association between exclusive breastfeeding and jaundice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.