ReviewEnvironmental microbiology2014
Amoeba host-Legionella synchronization of amino acid auxotrophy and its role in bacterial adaptation and pathogenic evolution.
Review in Environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026Review
- ThemSphere · 2025Article
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- Exploring interspecific interaction variability in microbiota: A review.Engineering microbiology · 2024Review
- Article
- Eat or Be Eaten: Strategies Used byInfection and immunity · 2023Review
- Pathogenicity and Virulence ofVirulence · 2021Review
- Evolution and Adaptation ofBiomolecules · 2021Review
- Nutrient Scarcity in a New Defined Medium Reveals Metabolic Resistance to Antibiotics in the Fish PathogenFrontiers in microbiology · 2021Article
- Mechanisms of Effector-Mediated Immunity Revealed by the Accidental Human PathogenFrontiers in cellular and infection microbiology · 2020Review
- Review
- Mammalian Solute Carrier (SLC)-like transporters of Legionella pneumophila.Scientific reports · 2018Article
- Article
- Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector.PLoS genetics · 2018Article
- Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane.Scientific reports · 2017Article
- Review
- Host FIH-Mediated Asparaginyl Hydroxylation of TranslocatedFrontiers in cellular and infection microbiology · 2017Article
- Occurrence of Legionella in wastewater treatment plants linked to wastewater characteristics.Environmental science and pollution research international · 2016Article
- Evolution of Bacterial Pathogens Within the Human Host.Microbiology spectrum · 2016Review
- Lysine11-Linked Polyubiquitination of the AnkB F-Box Effector of Legionella pneumophila.Infection and immunity · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Legionella pneumophila, the causative agent of Legionnaires' disease, invades and proliferates within a diverse range of free-living amoeba in the environment, but upon transmission to humans, the bacteria hijack alveolar macrophages. Intracellular proliferation of L. pneumophila in two evolutionarily distant hosts is facilitated by bacterial exploitation of conserved host processes that are targeted by bacterial protein effectors injected into the host cell. A key aspect of microbe-host interaction is microbial extraction of nutrients from the host, but understanding of this is still limited. AnkB functions as a nutritional virulence factor and promotes host proteasomal degradation of polyubiquitinated proteins generating gratuitous levels of limiting host cellular amino acids. Legionella pneumophila is auxotrophic for several amino acids including cysteine, which is a metabolically preferred source of carbon and energy during intracellular proliferation, but is limiting in both amoebae and humans. We propose that synchronization of bacterial amino acids auxotrophy with the host is a driving force in pathogenic evolution and nutritional adaptation of L. pneumophila and other intracellular bacteria to life within the host cell. Understanding microbial strategies of nutrient generation and acquisition in the host will provide novel antimicrobial strategies to disrupt pathogen access to essential sources of carbon and energy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.