ArticleAddiction (Abingdon, England)2014
Chronic hepatitis C virus infection is associated with all-cause and liver-related mortality in a cohort of HIV-infected patients with alcohol problems.
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Housing Status, Medical Care, and Health Outcomes Among People Living With HIV/AIDS: A Systematic Review.American journal of public health · 2016Pooled it
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- Situational and motivational factors associated with unhealthy alcohol use among Russian women with HIV and hepatitis C Virus co-infection.Drug and alcohol dependence reports · 2022Article
- Hepatitis C virus: A critical approach to who really needs treatment.World journal of hepatology · 2022Review
- Hepatitis C virus infection and risk of liver-related and non-liver-related deaths: a population-based cohort study in Naples, southern Italy.BMC infectious diseases · 2021Article
- Article
- Practice facilitation to implement alcohol-related care in Veterans Health Administration liver clinics: a study protocol.Implementation science communications · 2020Article
- Influence of comorbid drug use disorder on receipt of evidence-based treatment for alcohol use disorder among VA patients with alcohol use disorder and Hepatitis C and/or HIV.Drug and alcohol dependence · 2019Article
- Effect of Hepatocellular Carcinoma on Mortality Among Individuals With Hepatitis B or Hepatitis C Infection in New York City, 2001-2012.Open forum infectious diseases · 2018Article
- Hepatitis C infection substantially reduces survival of alcohol-dependent patients.Clinical epidemiology · 2018Article
- Direct and Indirect Effects of Heavy Alcohol Use on Clinical Outcomes in a Longitudinal Study of HIV Patients on ART.AIDS and behavior · 2017Article
- Effect of alcohol consumption on all-cause and liver-related mortality among HIV-infected individuals.HIV medicine · 2017Article
- Assessing the Effect of Potential Reductions in Non-Hepatic Mortality on the Estimated Cost-Effectiveness of Hepatitis C Treatment in Early Stages of Liver Disease.Applied health economics and health policy · 2017Article
- Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections.World journal of hepatology · 2016Review
- Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions.Alcoholism, clinical and experimental research · 2016Review
- Pain and Mortality Risk in a Cohort of HIV-Infected Persons with Alcohol Use Disorders.AIDS and behavior · 2016Article
- Impact of hepatitis C status on 20-year mortality of patients with substance use disorders.Addiction science & clinical practice · 2015Article
- Inflammatory cytokines and mortality in a cohort of HIV-infected adults with alcohol problems.AIDS (London, England) · 2014Article
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7 authors.
Funding
Abstract
aimsTo assess the association between hepatitis C virus (HCV) infection and overall and liver-related death in human immunodeficiency virus (HIV)-infected patients with alcohol problems.
designWe analyzed data from a cohort of HIV-infected adults with current or past alcohol problems enrolled between 2001 and 2003, searching for causes of death until 2010 using the National Death Index. SETTING AND
participantsParticipants were HIV-infected adults with current or past alcohol problems, recruited in Boston, MA from HIV clinics at two hospitals, homeless shelters, drug treatment programs, subject referrals, flyers and another cohort study with comparable recruitment sites. MEASUREMENTS: The primary and secondary outcomes were all-cause and liver-related mortality, respectively. The main independent variable was hepatitis C virus (HCV) RNA status (positive versus negative). Mortality rates and Kaplan-Meier survival curves were calculated by HCV status for both overall and liver-related mortality. Cox proportional hazards models were used to assess the association between HCV infection and overall and liver-related death, adjusting for alcohol and drug use over time.
findingsA total of 397 adults (50% HCV-infected) were included. As of 31 December 2009, 83 cohort participants had died (60 HCV-infected, 23 HCV-uninfected; log-rank test P < 0.001), and 26 of those deaths were liver-related (21 HCV-infected, five HCV-uninfected; log-rank test P < 0.001). All-cause and liver-related mortality rates were 4.68 and 1.64 deaths per 100 person-years for HCV-infected patients and 1.65 and 0.36 per 100 person-years for those without HCV, respectively. In the fully adjusted Cox model, HCV infection was associated with both overall [hazard ratio (HR) = 2.55, 95% confidence interval (CI) = 1.50-4.33, P < 0.01], and liver-related mortality (HR = 3.24, 95% CI = 1.18-8.94, P = 0.02].
conclusionHepatitis C virus infection is associated independently with all-cause and liver-related mortality in human immunodeficiency virus-infected patients with alcohol problems, even when accounting for alcohol and other drug use.
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