ArticleJournal of the American Chemical Society2013
Multicomponent reactions for de novo synthesis of BODIPY probes: in vivo imaging of phagocytic macrophages.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 150 citations in OpenAlex.
- Ratiometric pH-Responsive and Biomimetic Microparticles for Quantitative Monitoring of Phagosomal Acidification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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- Fluorogenic Platform for Real-Time Imaging of Subcellular Payload Release in Antibody-Drug Conjugates.Journal of the American Chemical Society · 2025Article
- Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Modulating and Imaging Macrophage Reprogramming for Cancer Immunotherapy.Phenomics (Cham, Switzerland) · 2024Review
- Inserting "OFF-to-ON" BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells.ACS central science · 2024Article
- HPW-Catalyzed environmentally benign approach to imidazo[1,2-Beilstein journal of organic chemistry · 2024Article
- Smart probes for optical imaging of T cells and screening of anti-cancer immunotherapies.Chemical Society reviews · 2023Review
- Multicomponent synthesis of chromophores - The one-pot approach to functional π-systems.Frontiers in chemistry · 2023Review
- Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target.Nature communications · 2022Article
- A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging.RSC chemical biology · 2022Article
- Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design.Biomedicines · 2022Review
- One Scaffold, Different Organelle Sensors: pH-Activable Fluorescent Probes for Targeting Live Microglial Cell Organelles.Chembiochem : a European journal of chemical biology · 2022Article
- Activatable Fluorophores for Imaging Immune Cell Function.Accounts of chemical research · 2022Review
- Late-stage C(spChemical science · 2020Article
- A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages.Angewandte Chemie (International ed. in English) · 2019Article
- The Groebke-Blackburn-Bienaymé Reaction.European journal of chemistry (Print) · 2019Article
- Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target.Nature communications · 2019Article
- Screening for new macrophage therapeutics.Theranostics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Multicomponent reactions are excellent tools to generate complex structures with broad chemical diversity and fluorescent properties. Herein we describe the adaptation of the fluorescent BODIPY scaffold to multicomponent reaction chemistry with the synthesis of BODIPY adducts with high fluorescence quantum yields and good cell permeability. From this library we identified one BODIPY derivative (PhagoGreen) as a low-pH sensing fluorescent probe that enabled imaging of phagosomal acidification in activated macrophages. The fluorescence emission of PhagoGreen was proportional to the degree of activation of macrophages and could be specifically blocked by bafilomycin A, an inhibitor of phagosomal acidification. PhagoGreen does not impair the normal functions of macrophages and can be used to image phagocytic macrophages in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.